Allosteric Modulation of Muscarinic Receptors

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F16%3A00458562" target="_blank" >RIV/67985823:_____/16:00458562 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/978-1-4939-2858-3_6" target="_blank" >http://dx.doi.org/10.1007/978-1-4939-2858-3_6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-1-4939-2858-3_6" target="_blank" >10.1007/978-1-4939-2858-3_6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Allosteric Modulation of Muscarinic Receptors

Popis výsledku v původním jazyce

Allosteric ligands modulate binding and function of muscarinic receptors in a different way than orthosteric ligands. Unlike orthosteric ligands their effects are limited by a cooperativity factor. This imparts them unique properties, including cooperativity-based selectivity, functional selectivity and restoring of physiological-like space and time pattern of signaling under pathological conditions. Therefore, allosteric modulators of muscarinic receptor are intensively studied as possible therapeutics of pathological conditions including Alzheimer’s disease and schizophrenia. Research of allosteric modulation has pioneered the way for a whole class A of G-protein coupled receptors and has had an impact beyond its own field. We review principles of allosteric modulations and their implications for proper design of binding as well as functional experiments and for proper data analysis.

Název v anglickém jazyce

Allosteric Modulation of Muscarinic Receptors

Popis výsledku anglicky

Allosteric ligands modulate binding and function of muscarinic receptors in a different way than orthosteric ligands. Unlike orthosteric ligands their effects are limited by a cooperativity factor. This imparts them unique properties, including cooperativity-based selectivity, functional selectivity and restoring of physiological-like space and time pattern of signaling under pathological conditions. Therefore, allosteric modulators of muscarinic receptor are intensively studied as possible therapeutics of pathological conditions including Alzheimer’s disease and schizophrenia. Research of allosteric modulation has pioneered the way for a whole class A of G-protein coupled receptors and has had an impact beyond its own field. We review principles of allosteric modulations and their implications for proper design of binding as well as functional experiments and for proper data analysis.

Druh

C - Kapitola v odborné knize

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

<a href="/cs/project/GBP304%2F12%2FG069" target="_blank" >GBP304/12/G069: Projekt excelence v oblasti neurověd</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Muscarinic Receptor: From Structure to Animal Models

ISBN

978-1-4939-2857-6

Počet stran výsledku

36

Strana od-do

95-130

Počet stran knihy

287

Název nakladatele

Springer

Místo vydání

New York

Kód UT WoS kapitoly

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