Native T1 Relaxation Time and Extracellular Volume Fraction as Accurate Markers of Diffuse Myocardial Fibrosis in Heart Valve Disease - Comparison With Targeted Left Ventricular Myocardial Biopsy -

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F16%3A00464970" target="_blank" >RIV/67985823:_____/16:00464970 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/16:10327254 RIV/00023001:_____/16:00059978 RIV/75010330:_____/16:00011365

Výsledek na webu

<a href="http://dx.doi.org/10.1253/circj.CJ-15-1309" target="_blank" >http://dx.doi.org/10.1253/circj.CJ-15-1309</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1253/circj.CJ-15-1309" target="_blank" >10.1253/circj.CJ-15-1309</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Native T1 Relaxation Time and Extracellular Volume Fraction as Accurate Markers of Diffuse Myocardial Fibrosis in Heart Valve Disease - Comparison With Targeted Left Ventricular Myocardial Biopsy -

Popis výsledku v původním jazyce

Background: The aim of our study was to investigate the relationship between the cardiac magnetic resonance (CMR)-derived native T1 relaxation time and myocardial extracellular volume (ECV) fraction and the extent of diffuse myocardial fibrosis (DMF) on targeted myocardial left ventricular (LV) biopsy. nnMethods and Results: The study population consisted of 40 patients (age 63 +/- 8 years, 65% male) undergoing valve and/or ascending aorta surgery for severe aortic stenosis (77.5%), root dilatation (7.5%) or valve regurgitation (15%). The T1 relaxation time was assessed in the basal interventricular septum pre-and 10-min post-contrast administration using the modified Look-Locker Inversion recovery sequence prior to surgery. LV myocardial biopsy specimen was obtained during surgery from the basal interventricular septal segment matched with the T1 mapping assessment. The percentage of myocardial collagen was quantified using picrosirius red staining. The average percentage of myocardial collagen was 22.0 +/- 14.8%. Both native T1 relaxation time with cutoff value >= 1,010 ms (sensitivity=90%, specificity=73%, area under the curve=0.82) and ECV with cutoff value >= 0.32 (sensitivity=80%, specificity=90%, area under the curve=0.85) showed high accuracy to identify severe (>30%) DMF. The native T1 relaxation time showed significant correlation with LV mass (P<0.01). nnConclusions: Native T1 relaxation time and ECV at 10 min after contrast administration are accurate markers of DMF.

Název v anglickém jazyce

Native T1 Relaxation Time and Extracellular Volume Fraction as Accurate Markers of Diffuse Myocardial Fibrosis in Heart Valve Disease - Comparison With Targeted Left Ventricular Myocardial Biopsy -

Popis výsledku anglicky

Background: The aim of our study was to investigate the relationship between the cardiac magnetic resonance (CMR)-derived native T1 relaxation time and myocardial extracellular volume (ECV) fraction and the extent of diffuse myocardial fibrosis (DMF) on targeted myocardial left ventricular (LV) biopsy. nnMethods and Results: The study population consisted of 40 patients (age 63 +/- 8 years, 65% male) undergoing valve and/or ascending aorta surgery for severe aortic stenosis (77.5%), root dilatation (7.5%) or valve regurgitation (15%). The T1 relaxation time was assessed in the basal interventricular septum pre-and 10-min post-contrast administration using the modified Look-Locker Inversion recovery sequence prior to surgery. LV myocardial biopsy specimen was obtained during surgery from the basal interventricular septal segment matched with the T1 mapping assessment. The percentage of myocardial collagen was quantified using picrosirius red staining. The average percentage of myocardial collagen was 22.0 +/- 14.8%. Both native T1 relaxation time with cutoff value >= 1,010 ms (sensitivity=90%, specificity=73%, area under the curve=0.82) and ECV with cutoff value >= 0.32 (sensitivity=80%, specificity=90%, area under the curve=0.85) showed high accuracy to identify severe (>30%) DMF. The native T1 relaxation time showed significant correlation with LV mass (P<0.01). nnConclusions: Native T1 relaxation time and ECV at 10 min after contrast administration are accurate markers of DMF.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EA - Morfologické obory a cytologie

OECD FORD obor

—

Projekt

<a href="/cs/project/GAP302%2F11%2F1308" target="_blank" >GAP302/11/1308: Epigenetické faktory ve formování myokardu</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Circulation Journal

ISSN

1346-9843

e-ISSN

—

Svazek periodika

80

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

JP - Japonsko

Počet stran výsledku

8

Strana od-do

1202-1209

Kód UT WoS článku

000377142700023

EID výsledku v databázi Scopus

2-s2.0-84964311224