Tempol and melatonin blunt antiarrhythmic effect of chronic intermittent hypoxia in rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F17%3A00477759" target="_blank" >RIV/67985823:_____/17:00477759 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Tempol and melatonin blunt antiarrhythmic effect of chronic intermittent hypoxia in rats

Popis výsledku v původním jazyce

The aim was to find out whether the antiarrhythmic protection conferred by chronic hypoxia involves reactive oxygen species (ROS). Adult male rats were adapted (24-30 exposures) to intermittent hypobaric hypoxia (IHH, 5000 m, 4 h, 5 day a week). Compared to normoxic rats, IHH significantly attenuated the burst of ROS associated with early reperfusion of isolated hearts following 15-min ischemia. The sensitivity of reperfusion arrhythmias was significantly lower in IHH hearts than in normoxic ones, in particular due to the reduced incidence of ventricular fibrillation. Tempo or melatonin given before ischemia decreased reperfusion arrhythmias in the normoxic group, but completely abolished the antiarrhythmic protection in IHH hearts. However, the effect of IHH still persisted in the hearts treated with melatonin only at reperfusion. These results suggest that IHH decreases cardiac susceptibility to reperfusion-induced ventricular arrhythmias via ROS-dependent mechanism during the ischemic period and limitation of oxidative stress at reflow.

Název v anglickém jazyce

Tempol and melatonin blunt antiarrhythmic effect of chronic intermittent hypoxia in rats

Popis výsledku anglicky

The aim was to find out whether the antiarrhythmic protection conferred by chronic hypoxia involves reactive oxygen species (ROS). Adult male rats were adapted (24-30 exposures) to intermittent hypobaric hypoxia (IHH, 5000 m, 4 h, 5 day a week). Compared to normoxic rats, IHH significantly attenuated the burst of ROS associated with early reperfusion of isolated hearts following 15-min ischemia. The sensitivity of reperfusion arrhythmias was significantly lower in IHH hearts than in normoxic ones, in particular due to the reduced incidence of ventricular fibrillation. Tempo or melatonin given before ischemia decreased reperfusion arrhythmias in the normoxic group, but completely abolished the antiarrhythmic protection in IHH hearts. However, the effect of IHH still persisted in the hearts treated with melatonin only at reperfusion. These results suggest that IHH decreases cardiac susceptibility to reperfusion-induced ventricular arrhythmias via ROS-dependent mechanism during the ischemic period and limitation of oxidative stress at reflow.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

30105 - Physiology (including cytology)

Projekt

<a href="/cs/project/GAP303%2F12%2F1162" target="_blank" >GAP303/12/1162: Interakce mezi dlouhodobými formami kardioprotekce vyvolané adaptací na chronickou hypoxii a pravidelnou fyzickou zátěží.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Adaptation biology and medicine : Current trends

ISBN

978-81-8487-567-6

Počet stran výsledku

11

Strana od-do

299-309

Počet stran knihy

480

Název nakladatele

Narosa Publishing House

Místo vydání

New Delhi

Kód UT WoS kapitoly

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