Noninvasive approach to mend the broken heart: Is “remote conditioning” a promising strategy for application in humans?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F17%3A00479718" target="_blank" >RIV/67985823:_____/17:00479718 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1139/cjpp-2017-0200" target="_blank" >http://dx.doi.org/10.1139/cjpp-2017-0200</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1139/cjpp-2017-0200" target="_blank" >10.1139/cjpp-2017-0200</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Noninvasive approach to mend the broken heart: Is “remote conditioning” a promising strategy for application in humans?

Popis výsledku v původním jazyce

Currently, there are no satisfactory interventions to protect the heart against the detrimental effects of ischemia-reperfusion injury. Although ischemic preconditioning (PC) is the most powerful form of intrinsic cardioprotection, its application in humans is limited to planned interventions, due to its short duration and technical requirements. However, many organs/tissues are capable of producing “remote” PC (RPC) when subjected to brief bouts of ischemia-reperfusion. RPC was first described in the heart where brief ischemia in one territory led to protection in other area. Later on, RPC started to be used in patients with acute myocardial infarction, albeit with ambiguous results. It is hypothesized that the connection between the signal triggered in remote organ and protection induced in the heart can be mediated by humoral and neural pathways, as well as via systemic response to short sublethal ischemia. However, although RPC has a potentially important clinical role, our understanding of the mechanistic pathways linking the local stimulus to the remote organ remains incomplete. Nevertheless, RPC appears as a cost-effective and easily performed intervention. Elucidation of protective mechanisms activated in the remote organ may have therapeutic and diagnostic implications in the management of myocardial ischemia and lead to development of pharmacological RPC mimetics.

Název v anglickém jazyce

Noninvasive approach to mend the broken heart: Is “remote conditioning” a promising strategy for application in humans?

Popis výsledku anglicky

Currently, there are no satisfactory interventions to protect the heart against the detrimental effects of ischemia-reperfusion injury. Although ischemic preconditioning (PC) is the most powerful form of intrinsic cardioprotection, its application in humans is limited to planned interventions, due to its short duration and technical requirements. However, many organs/tissues are capable of producing “remote” PC (RPC) when subjected to brief bouts of ischemia-reperfusion. RPC was first described in the heart where brief ischemia in one territory led to protection in other area. Later on, RPC started to be used in patients with acute myocardial infarction, albeit with ambiguous results. It is hypothesized that the connection between the signal triggered in remote organ and protection induced in the heart can be mediated by humoral and neural pathways, as well as via systemic response to short sublethal ischemia. However, although RPC has a potentially important clinical role, our understanding of the mechanistic pathways linking the local stimulus to the remote organ remains incomplete. Nevertheless, RPC appears as a cost-effective and easily performed intervention. Elucidation of protective mechanisms activated in the remote organ may have therapeutic and diagnostic implications in the management of myocardial ischemia and lead to development of pharmacological RPC mimetics.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30105 - Physiology (including cytology)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Canadian Journal of Physiology and Pharmacology

ISSN

0008-4212

e-ISSN

—

Svazek periodika

95

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

CA - Kanada

Počet stran výsledku

9

Strana od-do

1204-1212

Kód UT WoS článku

000411898100016

EID výsledku v databázi Scopus

2-s2.0-85030123291