Effect of increased left ventricle mass on ischemia assessment in electrocardiographic signals: rabbit isolated heart study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F17%3A00483081" target="_blank" >RIV/67985823:_____/17:00483081 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216305:26220/17:PU124244 RIV/00159816:_____/17:00068408 RIV/00216224:14110/17:00097870 RIV/00216208:11110/17:10361988

Výsledek na webu

<a href="http://dx.doi.org/10.1186/s12872-017-0652-9" target="_blank" >http://dx.doi.org/10.1186/s12872-017-0652-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12872-017-0652-9" target="_blank" >10.1186/s12872-017-0652-9</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of increased left ventricle mass on ischemia assessment in electrocardiographic signals: rabbit isolated heart study

Popis výsledku v původním jazyce

Detailed quantitative analysis of the effect of left ventricle (LV) hypertrophy on myocardial ischemia (MI) manifestation in ECG is still missing. In this study, rabbit isolated hearts with spontaneously increased LV mass were used to evaluate the effect of such LV alteration on ischemia detection kriteria. Methods: Electrophysiological effects of increased LV mass were evaluated on rabbit isolated hearts under non-ischemic and ischemic conditions by analysis of various electrogram (EG) parameters. To reveal hearts with increased LV mass, LV weight/heart weight ratio was proposed. Standard paired and unpaired statistical tests and receiver operating characteristics analysis were used to compare data derived from different groups of animals, monitor EG parameters during global ischemia and evaluate their ability to detect ischemic state. Results: Successful evaluation of both increased LV mass and ischemia is lead-dependent. Particularly, maximal deviation of QRS and area under QRS associated with anterolateral wall respond significantly to even early phase (the 1st-3rd min) of ischemia. Besides ischemia, these parameters reflect increased LV mass as well (sensitivity approx. 80%). However, the sensitivity of the parameters to both phenomena may lead to misinterpretations, when inappropriate criteria are selected. Particularly, use of cut-off-based criteria defined from control group for ischemia detection in hearts with increased LV mass may result in dramatic reduction (approx. 15%) of detection specificity due to increased number of false positives. Nevertheless, criteria adjusted to particular experimental group allow achieving ischemia detection sensitivity of 89-100% and specificity of 94-100%, respectively. Conclusions: It was shown that response of the heart to MI can be successfully evaluated only considering heart-related factors (LV mass) and other methodological aspects (recording electrodes position, selected EG parameters, cut-off criteria, etc.)

Název v anglickém jazyce

Effect of increased left ventricle mass on ischemia assessment in electrocardiographic signals: rabbit isolated heart study

Popis výsledku anglicky

Detailed quantitative analysis of the effect of left ventricle (LV) hypertrophy on myocardial ischemia (MI) manifestation in ECG is still missing. In this study, rabbit isolated hearts with spontaneously increased LV mass were used to evaluate the effect of such LV alteration on ischemia detection kriteria. Methods: Electrophysiological effects of increased LV mass were evaluated on rabbit isolated hearts under non-ischemic and ischemic conditions by analysis of various electrogram (EG) parameters. To reveal hearts with increased LV mass, LV weight/heart weight ratio was proposed. Standard paired and unpaired statistical tests and receiver operating characteristics analysis were used to compare data derived from different groups of animals, monitor EG parameters during global ischemia and evaluate their ability to detect ischemic state. Results: Successful evaluation of both increased LV mass and ischemia is lead-dependent. Particularly, maximal deviation of QRS and area under QRS associated with anterolateral wall respond significantly to even early phase (the 1st-3rd min) of ischemia. Besides ischemia, these parameters reflect increased LV mass as well (sensitivity approx. 80%). However, the sensitivity of the parameters to both phenomena may lead to misinterpretations, when inappropriate criteria are selected. Particularly, use of cut-off-based criteria defined from control group for ischemia detection in hearts with increased LV mass may result in dramatic reduction (approx. 15%) of detection specificity due to increased number of false positives. Nevertheless, criteria adjusted to particular experimental group allow achieving ischemia detection sensitivity of 89-100% and specificity of 94-100%, respectively. Conclusions: It was shown that response of the heart to MI can be successfully evaluated only considering heart-related factors (LV mass) and other methodological aspects (recording electrodes position, selected EG parameters, cut-off criteria, etc.)

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30105 - Physiology (including cytology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BMC Cardiovascular Disorders

ISSN

1471-2261

e-ISSN

—

Svazek periodika

17

Číslo periodika v rámci svazku

Aug 4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

—

Kód UT WoS článku

000406953000001

EID výsledku v databázi Scopus

2-s2.0-85026759078