Participation of GABA(B) receptors in cortical postictal excitability in immature rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F18%3A00488631" target="_blank" >RIV/67985823:_____/18:00488631 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.ejphar.2017.10.022" target="_blank" >http://dx.doi.org/10.1016/j.ejphar.2017.10.022</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ejphar.2017.10.022" target="_blank" >10.1016/j.ejphar.2017.10.022</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Participation of GABA(B) receptors in cortical postictal excitability in immature rats

Popis výsledku v původním jazyce

Arrest of seizures is due to an active inhibition and is followed in mature brain by period of refractoriness markedly present one min after the end of seizures. To study changes in cortical excitability after epileptic seizures we used electrical stimulation of sensorimotor cortical area in immature rats - 25-day-old ones with mature postictal refractoriness and 12-day-old where postictal potentiation of afterdischarges (ADs) is present instead of refractoriness at one minute after the end of the conditioning AD. GABA(B) receptor antagonist CGP35348 was found to partly suppress postictal refractoriness. In present study not only an antagonist CGP46381 (3 and 10 mg/kg i.p.) but also positive allosteric modulator of GABA(B) receptors CGP7930 ( 20 and 40 mg/kg i.p.) were used to study the role of GABA(B) receptors in both age groups. They were injected immediately after testing AD and 10 min later the two stimulations were repeated. CGP46381 partly antagonized postictal refractoriness in 25-day-old rats but did not significantly affect ADs in 12-day-old animals. CGP7930 did not significantly change ADs duration in either age group. GABAB receptors participate in mechanism of postictal refractoriness but did not play an important role in 12-day-old rats where potentiation instead of refractoriness is present.

Název v anglickém jazyce

Participation of GABA(B) receptors in cortical postictal excitability in immature rats

Popis výsledku anglicky

Arrest of seizures is due to an active inhibition and is followed in mature brain by period of refractoriness markedly present one min after the end of seizures. To study changes in cortical excitability after epileptic seizures we used electrical stimulation of sensorimotor cortical area in immature rats - 25-day-old ones with mature postictal refractoriness and 12-day-old where postictal potentiation of afterdischarges (ADs) is present instead of refractoriness at one minute after the end of the conditioning AD. GABA(B) receptor antagonist CGP35348 was found to partly suppress postictal refractoriness. In present study not only an antagonist CGP46381 (3 and 10 mg/kg i.p.) but also positive allosteric modulator of GABA(B) receptors CGP7930 ( 20 and 40 mg/kg i.p.) were used to study the role of GABA(B) receptors in both age groups. They were injected immediately after testing AD and 10 min later the two stimulations were repeated. CGP46381 partly antagonized postictal refractoriness in 25-day-old rats but did not significantly affect ADs in 12-day-old animals. CGP7930 did not significantly change ADs duration in either age group. GABAB receptors participate in mechanism of postictal refractoriness but did not play an important role in 12-day-old rats where potentiation instead of refractoriness is present.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Pharmacology

ISSN

0014-2999

e-ISSN

—

Svazek periodika

818

Číslo periodika v rámci svazku

Jan 5

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

4

Strana od-do

26-29

Kód UT WoS článku

000418522900004

EID výsledku v databázi Scopus

2-s2.0-85032856330