Developmental aspects of cardiac arrhythmias

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F18%3A00499945" target="_blank" >RIV/67985823:_____/18:00499945 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1093/med/9780198757269.003.0027" target="_blank" >http://dx.doi.org/10.1093/med/9780198757269.003.0027</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/med/9780198757269.003.0027" target="_blank" >10.1093/med/9780198757269.003.0027</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Developmental aspects of cardiac arrhythmias

Popis výsledku v původním jazyce

The rhythmic and synchronized contraction of atria and ventricles is essential for efficient pumping of blood throughout the body. This process relies on the proper generation and conduction of the cardiac electrical impulse. Electrophysiological properties differ in various regions of the heart, revealing intrinsic heterogeneities rooted, at least in part, in regional differences in expression of ion channel and gap junction subunit genes. A causal relation between transcription factors and such regionalized gene expression has been established. Abnormal cardiac electrical function and arrhythmias in the postnatal heart may stem from a developmental changes in gene regulation. Genome-wide association studies have provided strong evidence that common genetic variation at developmental gene loci modulates electrocardiographic indices of conduction and repolarization and susceptibility to arrhythmia. Functional aspects are illustrated by description of selected prenatally occurring arrhythmias and their possible mechanisms. We also discuss recent findings and provide background insight into these complex mechanisms.

Název v anglickém jazyce

Developmental aspects of cardiac arrhythmias

Popis výsledku anglicky

The rhythmic and synchronized contraction of atria and ventricles is essential for efficient pumping of blood throughout the body. This process relies on the proper generation and conduction of the cardiac electrical impulse. Electrophysiological properties differ in various regions of the heart, revealing intrinsic heterogeneities rooted, at least in part, in regional differences in expression of ion channel and gap junction subunit genes. A causal relation between transcription factors and such regionalized gene expression has been established. Abnormal cardiac electrical function and arrhythmias in the postnatal heart may stem from a developmental changes in gene regulation. Genome-wide association studies have provided strong evidence that common genetic variation at developmental gene loci modulates electrocardiographic indices of conduction and repolarization and susceptibility to arrhythmia. Functional aspects are illustrated by description of selected prenatally occurring arrhythmias and their possible mechanisms. We also discuss recent findings and provide background insight into these complex mechanisms.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

The ESC Textbook of Cardiovascular Development

ISBN

9780198757269

Počet stran výsledku

14

Strana od-do

269-282

Počet stran knihy

384

Název nakladatele

Oxford University Press

Místo vydání

Oxford

Kód UT WoS kapitoly

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