Developmental and sex differences in cardiac tolerance to ischemia-reperfusion injury: the role of mitochondria

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F19%3A00508598" target="_blank" >RIV/67985823:_____/19:00508598 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.nrcresearchpress.com/doi/10.1139/cjpp-2019-0060#.XljPJKhKiUk" target="_blank" >https://www.nrcresearchpress.com/doi/10.1139/cjpp-2019-0060#.XljPJKhKiUk</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1139/cjpp-2019-0060" target="_blank" >10.1139/cjpp-2019-0060</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Developmental and sex differences in cardiac tolerance to ischemia-reperfusion injury: the role of mitochondria

Popis výsledku v původním jazyce

Age and sex play an essential role in the cardiac tolerance to ischemia-reperfusion injury: cardiac resistance significantly decreases during postnatal maturation and the female heart is more tolerant than the male myocardium. It is widely accepted that mitochondrial dysfunction, and particularly mitochondrial permeability transition pore (MPTP) opening, plays a major role in determining the extent of cardiac ischemia-reperfusion injury. We have observed that the MPTP sensitivity to the calcium load differs in mitochondria isolated from neonatal and adult myocardium, as well as from adult male and female hearts. Neonatal and female mitochondria are more resistant both in the extent and in the rate of mitochondrial swelling induced by high calcium concentration. Our data further suggest that age-and sex-dependent specificity of the MPTP is not the result of different amounts of ATP synthase and cyclophilin D: neonatal and adult hearts, similarly as the male and female hearts, contain comparable amounts of MPTP and its regulatory protein cyclophilin D. We can speculate that the lower sensitivity of MPTP to the calcium-induced swelling may be related to the higher ischemic tolerance of both neonatal and female myocardium.

Název v anglickém jazyce

Developmental and sex differences in cardiac tolerance to ischemia-reperfusion injury: the role of mitochondria

Popis výsledku anglicky

Age and sex play an essential role in the cardiac tolerance to ischemia-reperfusion injury: cardiac resistance significantly decreases during postnatal maturation and the female heart is more tolerant than the male myocardium. It is widely accepted that mitochondrial dysfunction, and particularly mitochondrial permeability transition pore (MPTP) opening, plays a major role in determining the extent of cardiac ischemia-reperfusion injury. We have observed that the MPTP sensitivity to the calcium load differs in mitochondria isolated from neonatal and adult myocardium, as well as from adult male and female hearts. Neonatal and female mitochondria are more resistant both in the extent and in the rate of mitochondrial swelling induced by high calcium concentration. Our data further suggest that age-and sex-dependent specificity of the MPTP is not the result of different amounts of ATP synthase and cyclophilin D: neonatal and adult hearts, similarly as the male and female hearts, contain comparable amounts of MPTP and its regulatory protein cyclophilin D. We can speculate that the lower sensitivity of MPTP to the calcium-induced swelling may be related to the higher ischemic tolerance of both neonatal and female myocardium.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30105 - Physiology (including cytology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Canadian Journal of Physiology and Pharmacology

ISSN

0008-4212

e-ISSN

—

Svazek periodika

97

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

CA - Kanada

Počet stran výsledku

7

Strana od-do

808-814

Kód UT WoS článku

000483022200003

EID výsledku v databázi Scopus

2-s2.0-85068336761