A cytotoxicity and wear analysis of trapeziometacarpal total joint replacement implant consisting of DLC-coated Co-Cr-Mo alloy with the use of titanium gradient interlayer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F19%3A00509156" target="_blank" >RIV/67985823:_____/19:00509156 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21220/19:00332035

Výsledek na webu

<a href="https://doi.org/10.1016/j.diamond.2019.107456" target="_blank" >https://doi.org/10.1016/j.diamond.2019.107456</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.diamond.2019.107456" target="_blank" >10.1016/j.diamond.2019.107456</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A cytotoxicity and wear analysis of trapeziometacarpal total joint replacement implant consisting of DLC-coated Co-Cr-Mo alloy with the use of titanium gradient interlayer

Popis výsledku v původním jazyce

Diamond-like carbon (DLC) coatings exhibit excellent mechanical properties and improve the smoothness and the wear characteristic of the metallic component of total joint replacements. Although DLC is considered to be highly biocompatible, the effect of implant wear debris must be carefully analyzed. Simulated loading can help to mimic the wear of the implant in the human body over time. The purpose of the study presented here is to observe the wear of trapeziometacarpal (TMC) total joint arthroplasty implant consisting of DLC-coated Co-Cr-Mo alloy with the use of titanium gradient interlayer (Ti/Ti-C:H), and to analyze the potential cytotoxicity of the wear particles generated by simulated loading. No visible wear or delamination of the DLC coating was observed after 3 million cycles of increasing loading force up to 2.5 kN. Accordingly, no correlation was observed between increasing number of loading cycles (with increasing loading force) and decreasing proliferation of human osteoblast-like cells incubated in the wear suspension. We can therefore conclude that no cytotoxic wear debris was formed during the simulated loading of TMC total joint replacement implant composed of DLC-coated Co-Cr-Mo alloy with Ti/Ti-C:H gradient interlayer.

Název v anglickém jazyce

A cytotoxicity and wear analysis of trapeziometacarpal total joint replacement implant consisting of DLC-coated Co-Cr-Mo alloy with the use of titanium gradient interlayer

Popis výsledku anglicky

Diamond-like carbon (DLC) coatings exhibit excellent mechanical properties and improve the smoothness and the wear characteristic of the metallic component of total joint replacements. Although DLC is considered to be highly biocompatible, the effect of implant wear debris must be carefully analyzed. Simulated loading can help to mimic the wear of the implant in the human body over time. The purpose of the study presented here is to observe the wear of trapeziometacarpal (TMC) total joint arthroplasty implant consisting of DLC-coated Co-Cr-Mo alloy with the use of titanium gradient interlayer (Ti/Ti-C:H), and to analyze the potential cytotoxicity of the wear particles generated by simulated loading. No visible wear or delamination of the DLC coating was observed after 3 million cycles of increasing loading force up to 2.5 kN. Accordingly, no correlation was observed between increasing number of loading cycles (with increasing loading force) and decreasing proliferation of human osteoblast-like cells incubated in the wear suspension. We can therefore conclude that no cytotoxic wear debris was formed during the simulated loading of TMC total joint replacement implant composed of DLC-coated Co-Cr-Mo alloy with Ti/Ti-C:H gradient interlayer.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30404 - Biomaterials (as related to medical implants, devices, sensors)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Diamond and Related Materials

ISSN

0925-9635

e-ISSN

—

Svazek periodika

97

Číslo periodika v rámci svazku

Aug

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

7

Strana od-do

UNSP 107456

Kód UT WoS článku

000486134300030

EID výsledku v databázi Scopus

2-s2.0-85067806655