Interaction of GABA(A) and GABA(B) antagonists after status epilepticus in immature rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F20%3A00524266" target="_blank" >RIV/67985823:_____/20:00524266 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/j.yebeh.2019.106683" target="_blank" >https://doi.org/10.1016/j.yebeh.2019.106683</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.yebeh.2019.106683" target="_blank" >10.1016/j.yebeh.2019.106683</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Interaction of GABA(A) and GABA(B) antagonists after status epilepticus in immature rats

Popis výsledku v původním jazyce

Among neurotransmitter systems affected by status epilepticus (SE) in adult rats are both GABAeigic systems. To analyze possible changes of GABA(A) and GABA(B) systems in developing rats lithium-pilocarpine SE was induced at postnatal day 12 (P12). Seizures were elicited by a GABA(A) antagonist pentylenetetrazol (PTZ) 3, 6, 9, and 13 days after SE (i.e., in P15, P18, P21, and P25 rats), and their possible potentiation by a GABA(B) receptor antagonist CGP46381 was studied. Pilocalpine was replaced by saline in control animals (lithium-paraldehyde [LiPAR]).Pentylenetetrazol in a dose of 50 mg/kg s.c. elicited generalized seizures in nearly all 15-day-old naive rats and in 40% of 18-day-old ones but not in older animals. After SE, PTZ no longer elicited seizures in these two younger groups, i.e., sensitivity of GABA(A) system was diminished. The GABA(B) antagonist exhibited proconvulsant effect in P15 and P18 SE as well as LiPAR rats returning the incidence of PTZ-induced seizures to values of control animals. A decrease in the incidence of minimal clonic seizures was seen in P21 LiPAR animals, these seizures in the oldest group were not affected. Change of the effect from proconvulsant to anliconvulsant (or at least to no action) took place before postnatal day 21.Both SE and LiPAR animals exhibited similar changes but their intensity differed, effects in LiPAR controls were usually more expressed than in SE rats.

Název v anglickém jazyce

Interaction of GABA(A) and GABA(B) antagonists after status epilepticus in immature rats

Popis výsledku anglicky

Among neurotransmitter systems affected by status epilepticus (SE) in adult rats are both GABAeigic systems. To analyze possible changes of GABA(A) and GABA(B) systems in developing rats lithium-pilocarpine SE was induced at postnatal day 12 (P12). Seizures were elicited by a GABA(A) antagonist pentylenetetrazol (PTZ) 3, 6, 9, and 13 days after SE (i.e., in P15, P18, P21, and P25 rats), and their possible potentiation by a GABA(B) receptor antagonist CGP46381 was studied. Pilocalpine was replaced by saline in control animals (lithium-paraldehyde [LiPAR]).Pentylenetetrazol in a dose of 50 mg/kg s.c. elicited generalized seizures in nearly all 15-day-old naive rats and in 40% of 18-day-old ones but not in older animals. After SE, PTZ no longer elicited seizures in these two younger groups, i.e., sensitivity of GABA(A) system was diminished. The GABA(B) antagonist exhibited proconvulsant effect in P15 and P18 SE as well as LiPAR rats returning the incidence of PTZ-induced seizures to values of control animals. A decrease in the incidence of minimal clonic seizures was seen in P21 LiPAR animals, these seizures in the oldest group were not affected. Change of the effect from proconvulsant to anliconvulsant (or at least to no action) took place before postnatal day 21.Both SE and LiPAR animals exhibited similar changes but their intensity differed, effects in LiPAR controls were usually more expressed than in SE rats.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Epilepsy and Behavior

ISSN

1525-5050

e-ISSN

—

Svazek periodika

102

Číslo periodika v rámci svazku

Jan

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

106683

Kód UT WoS článku

000506868100045

EID výsledku v databázi Scopus

2-s2.0-85075217360