Omega-3 Phospholipids from Krill Oil Enhance Intestinal Fatty Acid Oxidation More Effectively than Omega-3 Triacylglycerols in High-Fat Diet-Fed Obese Mice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F20%3A00532017" target="_blank" >RIV/67985823:_____/20:00532017 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/20:10443074

Výsledek na webu

<a href="https://www.mdpi.com/2072-6643/12/7/2037" target="_blank" >https://www.mdpi.com/2072-6643/12/7/2037</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/nu12072037" target="_blank" >10.3390/nu12072037</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Omega-3 Phospholipids from Krill Oil Enhance Intestinal Fatty Acid Oxidation More Effectively than Omega-3 Triacylglycerols in High-Fat Diet-Fed Obese Mice

Popis výsledku v původním jazyce

Antisteatotic effects of omega-3 fatty acids (Omega-3) in obese rodents seem to vary depending on the lipid form of their administration. Whether these effects could reflect changes in intestinal metabolism is unknown. Here, we compare Omega-3-containing phospholipids (krill oil, omega 3PL-H) and triacylglycerols (omega 3TG) in terms of their effects on morphology, gene expression and fatty acid (FA) oxidation in the small intestine. Male C57BL/6N mice were fed for 8 weeks with a high-fat diet (HFD) alone or supplemented with 30 mg/g diet of omega 3TG or omega 3PL-H. Omega-3 index, reflecting the bioavailability of Omega-3, reached 12.5% and 7.5% in the omega 3PL-H and omega 3TG groups, respectively. Compared to HFD mice, omega 3PL-H but not omega 3TG animals had lower body weight gain (-40%), mesenteric adipose tissue (-43%), and hepatic lipid content (-64%). The highest number and expression level of regulated intestinal genes was observed in omega 3PL-H mice. The expression of FA omega-oxidation genes was enhanced in both Omega-3-supplemented groups, but gene expression within the FA beta-oxidation pathway and functional palmitate oxidation in the proximal ileum was significantly increased only in omega 3PL-H mice. In conclusion, enhanced intestinal FA oxidation could contribute to the strong antisteatotic effects of Omega-3 when administered as phospholipids to dietary obese mice.

Název v anglickém jazyce

Omega-3 Phospholipids from Krill Oil Enhance Intestinal Fatty Acid Oxidation More Effectively than Omega-3 Triacylglycerols in High-Fat Diet-Fed Obese Mice

Popis výsledku anglicky

Antisteatotic effects of omega-3 fatty acids (Omega-3) in obese rodents seem to vary depending on the lipid form of their administration. Whether these effects could reflect changes in intestinal metabolism is unknown. Here, we compare Omega-3-containing phospholipids (krill oil, omega 3PL-H) and triacylglycerols (omega 3TG) in terms of their effects on morphology, gene expression and fatty acid (FA) oxidation in the small intestine. Male C57BL/6N mice were fed for 8 weeks with a high-fat diet (HFD) alone or supplemented with 30 mg/g diet of omega 3TG or omega 3PL-H. Omega-3 index, reflecting the bioavailability of Omega-3, reached 12.5% and 7.5% in the omega 3PL-H and omega 3TG groups, respectively. Compared to HFD mice, omega 3PL-H but not omega 3TG animals had lower body weight gain (-40%), mesenteric adipose tissue (-43%), and hepatic lipid content (-64%). The highest number and expression level of regulated intestinal genes was observed in omega 3PL-H mice. The expression of FA omega-oxidation genes was enhanced in both Omega-3-supplemented groups, but gene expression within the FA beta-oxidation pathway and functional palmitate oxidation in the proximal ileum was significantly increased only in omega 3PL-H mice. In conclusion, enhanced intestinal FA oxidation could contribute to the strong antisteatotic effects of Omega-3 when administered as phospholipids to dietary obese mice.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

<a href="/cs/project/GA16-08124S" target="_blank" >GA16-08124S: Úloha střevní tkáně v rozdílném metabolickém účinku vybraných lipidových forem n-3 polynenasycených mastných kyselin</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nutrients

ISSN

2072-6643

e-ISSN

—

Svazek periodika

12

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

20

Strana od-do

2037

Kód UT WoS článku

000556892600001

EID výsledku v databázi Scopus

2-s2.0-85087630620