Left ventricular function and remodelling in rats exposed stepwise up to extreme chronic intermittent hypoxia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F20%3A00534241" target="_blank" >RIV/67985823:_____/20:00534241 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/20:10417662

Výsledek na webu

<a href="https://doi.org/10.1016/j.resp.2020.103526" target="_blank" >https://doi.org/10.1016/j.resp.2020.103526</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.resp.2020.103526" target="_blank" >10.1016/j.resp.2020.103526</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Left ventricular function and remodelling in rats exposed stepwise up to extreme chronic intermittent hypoxia

Popis výsledku v původním jazyce

The main aim was to find out whether long-lasting stepwise exposure to extreme hypoxia affects left ventricular (LV) geometry and systolic function. Adult male rats were exposed to intermittent hypobaric hypoxia (8 h/day) with increasing altitude in steps of 1000 m every 3 weeks up to 8000 m. While the LV cavity diastolic diameter did not change over the whole range of hypoxia, the wall thickness increased significantly at the altitude of 8000 m. LV fractional shortening ranged between 48.1 % and 50.1 % and remained unaffected even at the most severe hypoxia. At the end of experiment, haematocrit reached 83 %, mean systemic arterial pressure 120 % and relative LV weight 154 % of normoxic values while RV systolic pressure and relative RV weight doubled. Myocyte hypertrophy and myocardial fibrosis were more pronounced in RV than in LV. In conclusion, LV systolic function was preserved after chronic stepwise exposure of rats to extreme intermittent hypoxia despite moderate concentric hypertrophy and myocardial remodelling.

Název v anglickém jazyce

Left ventricular function and remodelling in rats exposed stepwise up to extreme chronic intermittent hypoxia

Popis výsledku anglicky

The main aim was to find out whether long-lasting stepwise exposure to extreme hypoxia affects left ventricular (LV) geometry and systolic function. Adult male rats were exposed to intermittent hypobaric hypoxia (8 h/day) with increasing altitude in steps of 1000 m every 3 weeks up to 8000 m. While the LV cavity diastolic diameter did not change over the whole range of hypoxia, the wall thickness increased significantly at the altitude of 8000 m. LV fractional shortening ranged between 48.1 % and 50.1 % and remained unaffected even at the most severe hypoxia. At the end of experiment, haematocrit reached 83 %, mean systemic arterial pressure 120 % and relative LV weight 154 % of normoxic values while RV systolic pressure and relative RV weight doubled. Myocyte hypertrophy and myocardial fibrosis were more pronounced in RV than in LV. In conclusion, LV systolic function was preserved after chronic stepwise exposure of rats to extreme intermittent hypoxia despite moderate concentric hypertrophy and myocardial remodelling.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30105 - Physiology (including cytology)

Projekt

<a href="/cs/project/GJ19-04790Y" target="_blank" >GJ19-04790Y: Efekt perinatální hypoxie a nízkoproteinové diety na úlohu RNA-demetylázy FTO v regulaci srdeční funkce a energetického metabolismu</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Respiratory Physiology & Neurobiology

ISSN

1569-9048

e-ISSN

—

Svazek periodika

282

Číslo periodika v rámci svazku

Nov

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

103526

Kód UT WoS článku

000579408900011

EID výsledku v databázi Scopus

2-s2.0-85089702185