The omega-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F20%3A00534257" target="_blank" >RIV/67985823:_____/20:00534257 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/20:10417007 RIV/00216208:11310/20:10417007 RIV/00023001:_____/20:00080289 RIV/00023736:_____/20:00013097 RIV/00064165:_____/20:10417007

Výsledek na webu

<a href="https://www.mdpi.com/2072-6643/12/8/2351" target="_blank" >https://www.mdpi.com/2072-6643/12/8/2351</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/nu12082351" target="_blank" >10.3390/nu12082351</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The omega-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach

Popis výsledku v původním jazyce

Omega-3 polyunsaturated fatty acids (omega-3PUFAs) are introduced into parenteral nutrition (PN) as hepatoprotective but may be susceptible to the lipid peroxidation while olive oil (OO) is declared more peroxidation resistant. We aimed to estimate how the lipid composition of PN mixture affects plasma and erythrocyte lipidome and the propensity of oxidative stress. A cross-sectional comparative study was performed in a cohort of adult patients who were long-term parenterally administered omega-3 PUFAs without (FO/-,n= 9) or with (FO/OO,n= 13) olive oil and healthy age- and sex-matched controls, (n= 30). Lipoperoxidation assessed as plasma and erythrocyte malondialdehyde content was increased in both FO/- and FO/OO groups but protein oxidative stress (protein carbonyls in plasma) and low redox status (GSH/GSSG in erythrocytes) was detected only in the FO/- subcohort. The lipidome of all subjects receiving omega-3 PUFAs was enriched with lipid species containing omega-3 PUFAs (FO/->FO/OO). Common characteristic of all PN-dependent patients was high content of fatty acyl-esters of hydroxy-fatty acids (FAHFAs) in plasma while acylcarnitines and ceramides were enriched in erythrocytes. Plasma and erythrocyte concentrations of plasmanyls and plasmalogens (endogenous antioxidants) were decreased in both patient groups with a significantly more pronounced effect in FO/-. We confirmed the protective effect of OO in PN mixtures containing omega-3 PUFAs.

Název v anglickém jazyce

The omega-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach

Popis výsledku anglicky

Omega-3 polyunsaturated fatty acids (omega-3PUFAs) are introduced into parenteral nutrition (PN) as hepatoprotective but may be susceptible to the lipid peroxidation while olive oil (OO) is declared more peroxidation resistant. We aimed to estimate how the lipid composition of PN mixture affects plasma and erythrocyte lipidome and the propensity of oxidative stress. A cross-sectional comparative study was performed in a cohort of adult patients who were long-term parenterally administered omega-3 PUFAs without (FO/-,n= 9) or with (FO/OO,n= 13) olive oil and healthy age- and sex-matched controls, (n= 30). Lipoperoxidation assessed as plasma and erythrocyte malondialdehyde content was increased in both FO/- and FO/OO groups but protein oxidative stress (protein carbonyls in plasma) and low redox status (GSH/GSSG in erythrocytes) was detected only in the FO/- subcohort. The lipidome of all subjects receiving omega-3 PUFAs was enriched with lipid species containing omega-3 PUFAs (FO/->FO/OO). Common characteristic of all PN-dependent patients was high content of fatty acyl-esters of hydroxy-fatty acids (FAHFAs) in plasma while acylcarnitines and ceramides were enriched in erythrocytes. Plasma and erythrocyte concentrations of plasmanyls and plasmalogens (endogenous antioxidants) were decreased in both patient groups with a significantly more pronounced effect in FO/-. We confirmed the protective effect of OO in PN mixtures containing omega-3 PUFAs.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30308 - Nutrition, Dietetics

Projekt

<a href="/cs/project/NV15-28745A" target="_blank" >NV15-28745A: Nutriční terapie nemocí jater různé etiologie: vliv n-3 mastných kyselin</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nutrients

ISSN

2072-6643

e-ISSN

—

Svazek periodika

12

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

15

Strana od-do

2351

Kód UT WoS článku

000579708700001

EID výsledku v databázi Scopus

2-s2.0-85089360250