Antioxidant Synergy of Mitochondrial Phospholipase PNPLA8/iPLA2 gamma with Fatty Acid-Conducting SLC25 Gene Family Transporters

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F21%3A00542843" target="_blank" >RIV/67985823:_____/21:00542843 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.mdpi.com/2076-3921/10/5/678" target="_blank" >https://www.mdpi.com/2076-3921/10/5/678</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/antiox10050678" target="_blank" >10.3390/antiox10050678</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Antioxidant Synergy of Mitochondrial Phospholipase PNPLA8/iPLA2 gamma with Fatty Acid-Conducting SLC25 Gene Family Transporters

Popis výsledku v původním jazyce

Patatin-like phospholipase domain-containing protein PNPLA8, also termed Ca2+-independent phospholipase A2 gamma (iPLA2 gamma), is addressed to the mitochondrial matrix (or peroxisomes), where it may manifest its unique activity to cleave phospholipid side-chains from both sn-1 and sn-2 positions, consequently releasing either saturated or unsaturated fatty acids (FAs), including oxidized FAs. Moreover, iPLA2 gamma is directly stimulated by H2O2 and, hence, is activated by redox signaling or oxidative stress. This redox activation permits the antioxidant synergy with mitochondrial uncoupling proteins (UCPs) or other SLC25 mitochondrial carrier family members by FA-mediated protonophoretic activity, termed mild uncoupling, that leads to diminishing of mitochondrial superoxide formation. This mechanism allows for the maintenance of the steady-state redox status of the cell. Besides the antioxidant role, we review the relations of iPLA2 gamma to lipid peroxidation since iPLA2 gamma is alternatively activated by cardiolipin hydroperoxides and hypothetically by structural alterations of lipid bilayer due to lipid peroxidation. Other iPLA2 gamma roles include the remodeling of mitochondrial (or peroxisomal) membranes and the generation of specific lipid second messengers. Thus, for example, during FA beta-oxidation in pancreatic beta-cells, H2O2-activated iPLA2 gamma supplies the GPR40 metabotropic FA receptor to amplify FA-stimulated insulin secretion. Cytoprotective roles of iPLA2 gamma in the heart and brain are also discussed.

Název v anglickém jazyce

Antioxidant Synergy of Mitochondrial Phospholipase PNPLA8/iPLA2 gamma with Fatty Acid-Conducting SLC25 Gene Family Transporters

Popis výsledku anglicky

Patatin-like phospholipase domain-containing protein PNPLA8, also termed Ca2+-independent phospholipase A2 gamma (iPLA2 gamma), is addressed to the mitochondrial matrix (or peroxisomes), where it may manifest its unique activity to cleave phospholipid side-chains from both sn-1 and sn-2 positions, consequently releasing either saturated or unsaturated fatty acids (FAs), including oxidized FAs. Moreover, iPLA2 gamma is directly stimulated by H2O2 and, hence, is activated by redox signaling or oxidative stress. This redox activation permits the antioxidant synergy with mitochondrial uncoupling proteins (UCPs) or other SLC25 mitochondrial carrier family members by FA-mediated protonophoretic activity, termed mild uncoupling, that leads to diminishing of mitochondrial superoxide formation. This mechanism allows for the maintenance of the steady-state redox status of the cell. Besides the antioxidant role, we review the relations of iPLA2 gamma to lipid peroxidation since iPLA2 gamma is alternatively activated by cardiolipin hydroperoxides and hypothetically by structural alterations of lipid bilayer due to lipid peroxidation. Other iPLA2 gamma roles include the remodeling of mitochondrial (or peroxisomal) membranes and the generation of specific lipid second messengers. Thus, for example, during FA beta-oxidation in pancreatic beta-cells, H2O2-activated iPLA2 gamma supplies the GPR40 metabotropic FA receptor to amplify FA-stimulated insulin secretion. Cytoprotective roles of iPLA2 gamma in the heart and brain are also discussed.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/LTAUSA17174" target="_blank" >LTAUSA17174: Úloha antioxidantů a mitochondriální fosfolipázy iPLA2γ v ochraně proti cerebrální ischemii</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Antioxidants

ISSN

2076-3921

e-ISSN

2076-3921

Svazek periodika

10

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

25

Strana od-do

678

Kód UT WoS článku

000653353600001

EID výsledku v databázi Scopus

2-s2.0-85104625325