Ictal Gamma-Band Interactions Localize Ictogenic Nodes of the Epileptic Network in Focal Cortical Dysplasia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F21%3A00543462" target="_blank" >RIV/67985823:_____/21:00543462 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985807:_____/21:00543462 RIV/00023752:_____/21:43920629 RIV/00216208:11130/21:10428678 RIV/68407700:21230/21:00350090 RIV/00064203:_____/21:10428678

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.clinph.2021.04.016" target="_blank" >http://dx.doi.org/10.1016/j.clinph.2021.04.016</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clinph.2021.04.016" target="_blank" >10.1016/j.clinph.2021.04.016</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Ictal Gamma-Band Interactions Localize Ictogenic Nodes of the Epileptic Network in Focal Cortical Dysplasia

Popis výsledku v původním jazyce

Objective: Epilepsy surgery fails in > 30% of patients with focal cortical dysplasia (FCD). The seizure persistence after surgery can be attributed to the inability to precisely localize the tissue with an endogenous potential to generate seizures. In this study, we aimed to identify the critical components of the epileptic network that were actively involved in seizure genesis. Methods: The directed transfer function was applied to intracranial EEG recordings and the effective connectivity was determined with a high temporal and frequency resolution. Pre-ictal network properties were compared with ictal epochs to identify regions actively generating ictal activity and discriminate them from the areas of propagation. Results: Analysis of 276 seizures from 30 patients revealed the existence of a seizure-related network reconfiguration in the gamma-band (25–170 Hz, p < 0.005) – ictogenic nodes. Unlike seizure onset zone, resecting the majority of ictogenic nodes correlated with favorable outcomes (p < 0.012). Conclusion: The prerequisite to successful epilepsy surgery is the accurate identification of brain areas from which seizures arise. We show that in FCD-related epilepsy, gamma-band network markers can reliably identify and distinguish ictogenic areas in macroelectrode recordings, improve intracranial EEG interpretation and better delineate the epileptogenic zone. Significance: Ictogenic nodes localize the critical parts of the epileptogenic tissue and increase the diagnostic yield of intracranial evaluation.

Název v anglickém jazyce

Ictal Gamma-Band Interactions Localize Ictogenic Nodes of the Epileptic Network in Focal Cortical Dysplasia

Popis výsledku anglicky

Objective: Epilepsy surgery fails in > 30% of patients with focal cortical dysplasia (FCD). The seizure persistence after surgery can be attributed to the inability to precisely localize the tissue with an endogenous potential to generate seizures. In this study, we aimed to identify the critical components of the epileptic network that were actively involved in seizure genesis. Methods: The directed transfer function was applied to intracranial EEG recordings and the effective connectivity was determined with a high temporal and frequency resolution. Pre-ictal network properties were compared with ictal epochs to identify regions actively generating ictal activity and discriminate them from the areas of propagation. Results: Analysis of 276 seizures from 30 patients revealed the existence of a seizure-related network reconfiguration in the gamma-band (25–170 Hz, p < 0.005) – ictogenic nodes. Unlike seizure onset zone, resecting the majority of ictogenic nodes correlated with favorable outcomes (p < 0.012). Conclusion: The prerequisite to successful epilepsy surgery is the accurate identification of brain areas from which seizures arise. We show that in FCD-related epilepsy, gamma-band network markers can reliably identify and distinguish ictogenic areas in macroelectrode recordings, improve intracranial EEG interpretation and better delineate the epileptogenic zone. Significance: Ictogenic nodes localize the critical parts of the epileptogenic tissue and increase the diagnostic yield of intracranial evaluation.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Neurophysiology

ISSN

1388-2457

e-ISSN

1872-8952

Svazek periodika

132

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

10

Strana od-do

1927-1936

Kód UT WoS článku

000674175200021

EID výsledku v databázi Scopus

2-s2.0-85109523613