Roles of the ventral hippocampus and medial prefrontal cortex in spatial reversal learning and attentional set-shifting

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F21%3A00545464" target="_blank" >RIV/67985823:_____/21:00545464 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/j.nlm.2021.107477" target="_blank" >https://doi.org/10.1016/j.nlm.2021.107477</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.nlm.2021.107477" target="_blank" >10.1016/j.nlm.2021.107477</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Roles of the ventral hippocampus and medial prefrontal cortex in spatial reversal learning and attentional set-shifting

Popis výsledku v původním jazyce

Neural components enabling flexible cognition and behavior are well-established, and depend mostly on proper intercommunication within the prefrontal cortex (PFC) and striatum. However, dense projections from the ventral hippocampus (vHPC) alter the functioning of the medial PFC (mPFC). Dysfunctional hippocampo-prefrontal connectivity negatively affects the integrity of flexible cognition, especially in patients with schizophrenia. In this study, we aimed to test the role of the vHPC and mPFC in a place avoidance task on a rotating arena using two spatial flexibility task variants – reversal learning and set-shifting. To achieve this, we inactivated each of these structures in adult male Long-Evans rats by performing bilateral local muscimol (a GABAA receptor agonist) injections. A significantly disrupted performance was observed in reversal learning in the vHPC-inactivated, but not in the mPFC-inactivated rats. These results confirm the notion that the vHPC participates in some forms of behavioral flexibility, especially when spatial cues are needed. It seems, rather unexpectedly, that the mPFC is not taxed in these flexibility tasks on a rotating arena.

Název v anglickém jazyce

Roles of the ventral hippocampus and medial prefrontal cortex in spatial reversal learning and attentional set-shifting

Popis výsledku anglicky

Neural components enabling flexible cognition and behavior are well-established, and depend mostly on proper intercommunication within the prefrontal cortex (PFC) and striatum. However, dense projections from the ventral hippocampus (vHPC) alter the functioning of the medial PFC (mPFC). Dysfunctional hippocampo-prefrontal connectivity negatively affects the integrity of flexible cognition, especially in patients with schizophrenia. In this study, we aimed to test the role of the vHPC and mPFC in a place avoidance task on a rotating arena using two spatial flexibility task variants – reversal learning and set-shifting. To achieve this, we inactivated each of these structures in adult male Long-Evans rats by performing bilateral local muscimol (a GABAA receptor agonist) injections. A significantly disrupted performance was observed in reversal learning in the vHPC-inactivated, but not in the mPFC-inactivated rats. These results confirm the notion that the vHPC participates in some forms of behavioral flexibility, especially when spatial cues are needed. It seems, rather unexpectedly, that the mPFC is not taxed in these flexibility tasks on a rotating arena.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neurobiology of Learning and Memory

ISSN

1074-7427

e-ISSN

1095-9564

Svazek periodika

183

Číslo periodika v rámci svazku

September 2021

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

107477

Kód UT WoS článku

000681199700009

EID výsledku v databázi Scopus

2-s2.0-85107988227