Toward building mass spectrometry-based metabolomics and lipidomics atlases for biological and clinical research
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F23%3A00570367" target="_blank" >RIV/67985823:_____/23:00570367 - isvavai.cz</a>
Výsledek na webu
<a href="https://doi.org/10.1016/j.trac.2022.116825" target="_blank" >https://doi.org/10.1016/j.trac.2022.116825</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.trac.2022.116825" target="_blank" >10.1016/j.trac.2022.116825</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Toward building mass spectrometry-based metabolomics and lipidomics atlases for biological and clinical research
Popis výsledku v původním jazyce
Current metabolomics and lipidomics studies are limited in the number of examined matrices, the breadth and scope of methods, reporting the number of metabolites, and data sharing. Here, we discuss the concept of metabolomics and lipidomics atlases that characterize the quantitative distribution and relationships of metabolites in biological matrices and serve as a resource for future studies. Combined sample extraction is recommended to screen the metabolome and lipidome comprehensively. A multiplatform mass spectrometry-based approach with methods for each fraction should follow to separate and detect metabolites differing in their physicochemical properties. Since many known metabolites are detected through untargeted analysis, routine use of multiple internal standards for quantification is advised. This approach provides semiquantitative data and delivers molar concentrations for selected polar metabolites and lipids. An interactive web tool to query metabolites, generate statistical models, visualize data, and download the results should be developed to access generated data easily.
Název v anglickém jazyce
Toward building mass spectrometry-based metabolomics and lipidomics atlases for biological and clinical research
Popis výsledku anglicky
Current metabolomics and lipidomics studies are limited in the number of examined matrices, the breadth and scope of methods, reporting the number of metabolites, and data sharing. Here, we discuss the concept of metabolomics and lipidomics atlases that characterize the quantitative distribution and relationships of metabolites in biological matrices and serve as a resource for future studies. Combined sample extraction is recommended to screen the metabolome and lipidome comprehensively. A multiplatform mass spectrometry-based approach with methods for each fraction should follow to separate and detect metabolites differing in their physicochemical properties. Since many known metabolites are detected through untargeted analysis, routine use of multiple internal standards for quantification is advised. This approach provides semiquantitative data and delivers molar concentrations for selected polar metabolites and lipids. An interactive web tool to query metabolites, generate statistical models, visualize data, and download the results should be developed to access generated data easily.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10406 - Analytical chemistry
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2023
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
TrAC-Trends in Analytical Chemistry
ISSN
0165-9936
e-ISSN
1879-3142
Svazek periodika
158
Číslo periodika v rámci svazku
January
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
21
Strana od-do
116825
Kód UT WoS článku
000995351600001
EID výsledku v databázi Scopus
2-s2.0-85142678094