In vivo and in vitro study of resorbable magnesium wires for medical implants: Mg purity, surface quality, Zn alloying and polymer coating

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F24%3A00587722" target="_blank" >RIV/67985823:_____/24:00587722 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378271:_____/24:00587722 RIV/67985891:_____/24:00587722 RIV/68407700:21340/24:00376025 RIV/00216208:11110/24:10481650 a 2 dalších

Výsledek na webu

<a href="https://hdl.handle.net/11104/0354828" target="_blank" >https://hdl.handle.net/11104/0354828</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jma.2024.06.003" target="_blank" >10.1016/j.jma.2024.06.003</a>

Jazyk výsledku

angličtina

Název v původním jazyce

In vivo and in vitro study of resorbable magnesium wires for medical implants: Mg purity, surface quality, Zn alloying and polymer coating

Popis výsledku v původním jazyce

Magnesium is an excellent material in terms of biocompatibility and its corrosion products can serve as an active source for new bone formation. Utilizing low-alloyed Mg-Zn wires can strongly reduce problems with large H2 bubbles and improve the mechanical properties. Acidic pickling and a polymer coating can be effectively used to lower the rate of in vivo degradation. In this work, microstructural, mechanical, and in vitro characterization of 250 µm and 300 µm extruded wires made from ultra-pure Mg, commercially pure Mg, Mg-0.15Zn, Mg-0.4Zn and Mg-1Zn was performed. Additionally, Mg-0.4Zn wires together with a variant coated with a copolymer of l-lactide and ε-caprolactone were tested in vivo on artificially damaged Wistar rat femurs. Based on the observed Mg-induced osteogenesis, polymer-coated Mg wires with a small addition of Zn are a perspective material for bone-support applications, such as cerclage and fixation wires.

Název v anglickém jazyce

In vivo and in vitro study of resorbable magnesium wires for medical implants: Mg purity, surface quality, Zn alloying and polymer coating

Popis výsledku anglicky

Magnesium is an excellent material in terms of biocompatibility and its corrosion products can serve as an active source for new bone formation. Utilizing low-alloyed Mg-Zn wires can strongly reduce problems with large H2 bubbles and improve the mechanical properties. Acidic pickling and a polymer coating can be effectively used to lower the rate of in vivo degradation. In this work, microstructural, mechanical, and in vitro characterization of 250 µm and 300 µm extruded wires made from ultra-pure Mg, commercially pure Mg, Mg-0.15Zn, Mg-0.4Zn and Mg-1Zn was performed. Additionally, Mg-0.4Zn wires together with a variant coated with a copolymer of l-lactide and ε-caprolactone were tested in vivo on artificially damaged Wistar rat femurs. Based on the observed Mg-induced osteogenesis, polymer-coated Mg wires with a small addition of Zn are a perspective material for bone-support applications, such as cerclage and fixation wires.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30404 - Biomaterials (as related to medical implants, devices, sensors)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Magnesium and Alloys

ISSN

2213-9567

e-ISSN

2213-9567

Svazek periodika

12

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

CN - Čínská lidová republika

Počet stran výsledku

17

Strana od-do

2472-2488

Kód UT WoS článku

001273472800001

EID výsledku v databázi Scopus

2-s2.0-85196953966