Thermosensing ability of TRPC5: current knowledge and unsettled questions

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F24%3A00599369" target="_blank" >RIV/67985823:_____/24:00599369 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/24:10487401

Výsledek na webu

<a href="https://doi.org/10.1186/s12576-024-00942-3" target="_blank" >https://doi.org/10.1186/s12576-024-00942-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12576-024-00942-3" target="_blank" >10.1186/s12576-024-00942-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Thermosensing ability of TRPC5: current knowledge and unsettled questions

Popis výsledku v původním jazyce

Our understanding of how the mammalian somatosensory system detects noxious cold is still limited. While the role of TRPM8 in signaling mild non-noxious coolness is reasonably understood, the molecular identity of channels transducing painful cold stimuli remains unresolved. TRPC5 was originally described to contribute to moderate cold responses of dorsal root ganglia neurons in vitro, but mice lacking TRPC5 exhibited no change in behavioral responses to cold temperature. The question of why a channel endowed with the ability to be activated by cooling contributes to the cold response only under certain conditions is currently being intensively studied. It seems increasingly likely that the physiological detection of cold temperatures involves multiple different channels and mechanisms that modulate the threshold and intensity of perception. In this review, we aim to outline how TRPC5 may contribute to these mechanisms and what molecular features are important for its role as a cold sensor.

Název v anglickém jazyce

Thermosensing ability of TRPC5: current knowledge and unsettled questions

Popis výsledku anglicky

Our understanding of how the mammalian somatosensory system detects noxious cold is still limited. While the role of TRPM8 in signaling mild non-noxious coolness is reasonably understood, the molecular identity of channels transducing painful cold stimuli remains unresolved. TRPC5 was originally described to contribute to moderate cold responses of dorsal root ganglia neurons in vitro, but mice lacking TRPC5 exhibited no change in behavioral responses to cold temperature. The question of why a channel endowed with the ability to be activated by cooling contributes to the cold response only under certain conditions is currently being intensively studied. It seems increasingly likely that the physiological detection of cold temperatures involves multiple different channels and mechanisms that modulate the threshold and intensity of perception. In this review, we aim to outline how TRPC5 may contribute to these mechanisms and what molecular features are important for its role as a cold sensor.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/GA22-13750S" target="_blank" >GA22-13750S: Signální dráhy ovlivňující funkci lidského TRPC5 receptoru: predikce jejich vztahu k bolesti při revmatoidní artritidě</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Physiological Sciences

ISSN

1880-6546

e-ISSN

1880-6562

Svazek periodika

74

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

50

Kód UT WoS článku

001325746800002

EID výsledku v databázi Scopus

2-s2.0-85205605532