Distinct retinal ganglion cell types in strictly subterranean, naturally microphthalmic mammals

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F25%3A00605155" target="_blank" >RIV/67985823:_____/25:00605155 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378050:_____/25:00645612 RIV/00216208:11310/25:10508230 RIV/60460709:41320/25:102942

Výsledek na webu

<a href="https://doi.org/10.1098/rspb.2024.2586" target="_blank" >https://doi.org/10.1098/rspb.2024.2586</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1098/rspb.2024.2586" target="_blank" >10.1098/rspb.2024.2586</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Distinct retinal ganglion cell types in strictly subterranean, naturally microphthalmic mammals

Popis výsledku v původním jazyce

African mole-rats (Bathyergidae, Rodentia) are subterranean rodents that live in extensive dark underground tunnel systems and rarely emerge aboveground. They can discriminate between light and dark but show no overt visually driven behaviours except for light-avoidance responses. Their eyes and central visual system are strongly reduced but not degenerated. Here, we focus on retinal ganglion cells (RGCs). Sighted mammals have numerous RGC types with distinct morphological and functional properties that encode different aspects of a visual scene. We analysed the morphological diversity of 216 intracellularly dye-injected RGCs in the giant mole-rat (Fukomys mechowii) and 48 RGCs in Ansell's mole-rat (Fukomys anselli). Using a hierarchical cluster analysis on 11 morphological parameters, we show that both species possess at least five RGC types with distinct dendritic field sizes and branching patterns. These resemble some RGC types of the mouse and rat, but mole-rat RGCs feature overall sparser and more asymmetric branching patterns. The dendritic trees of most RGCs in all clusters are monostratified in the inner plexiform layer, but bistratified and multistratified/diffuse cells also exist. Thus, although RGC morphologies have become disorganized, the basic retinal organization principle of parallel information processing by distinct RGC types is retained.

Název v anglickém jazyce

Distinct retinal ganglion cell types in strictly subterranean, naturally microphthalmic mammals

Popis výsledku anglicky

African mole-rats (Bathyergidae, Rodentia) are subterranean rodents that live in extensive dark underground tunnel systems and rarely emerge aboveground. They can discriminate between light and dark but show no overt visually driven behaviours except for light-avoidance responses. Their eyes and central visual system are strongly reduced but not degenerated. Here, we focus on retinal ganglion cells (RGCs). Sighted mammals have numerous RGC types with distinct morphological and functional properties that encode different aspects of a visual scene. We analysed the morphological diversity of 216 intracellularly dye-injected RGCs in the giant mole-rat (Fukomys mechowii) and 48 RGCs in Ansell's mole-rat (Fukomys anselli). Using a hierarchical cluster analysis on 11 morphological parameters, we show that both species possess at least five RGC types with distinct dendritic field sizes and branching patterns. These resemble some RGC types of the mouse and rat, but mole-rat RGCs feature overall sparser and more asymmetric branching patterns. The dendritic trees of most RGCs in all clusters are monostratified in the inner plexiform layer, but bistratified and multistratified/diffuse cells also exist. Thus, although RGC morphologies have become disorganized, the basic retinal organization principle of parallel information processing by distinct RGC types is retained.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

Projekt

<a href="/cs/project/GA22-35153S" target="_blank" >GA22-35153S: Počty neuronů v mozcích ptáků: Implikace pro evoluci ptačí inteligence</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Proceedings of the Royal Society B-Biological Sciences

ISSN

0962-8452

e-ISSN

1471-2954

Svazek periodika

292

Číslo periodika v rámci svazku

2038

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

20242586

Kód UT WoS článku

001397283800011

EID výsledku v databázi Scopus

2-s2.0-85215758885