EndoCompass project: research roadmap for calcium and bone endocrinology

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F25%3A00640505" target="_blank" >RIV/67985823:_____/25:00640505 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1093/ejendo/lvaf064" target="_blank" >https://doi.org/10.1093/ejendo/lvaf064</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/ejendo/lvaf064" target="_blank" >10.1093/ejendo/lvaf064</a>

Jazyk výsledku

angličtina

Název v původním jazyce

EndoCompass project: research roadmap for calcium and bone endocrinology

Popis výsledku v původním jazyce

Background Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding towards endocrinology. The EndoCompass project-a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology-aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.Methods Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation in bone and calcium endocrinology was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups.Results Research priorities encompass primary hyperparathyroidism, chronic hypoparathyroidism, and rare calcium-phosphate disorders. Key areas include bone as endocrine organ, bone mass acquisition, secondary osteoporosis, and skeletal dysplasias. Special emphasis is placed on cellular senescence, sex-specific differences in disease manifestation, and development of novel diagnostic tools for bone quality assessment.Conclusions This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into metabolic bone disease pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of these disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.

Název v anglickém jazyce

EndoCompass project: research roadmap for calcium and bone endocrinology

Popis výsledku anglicky

Background Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding towards endocrinology. The EndoCompass project-a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology-aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.Methods Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation in bone and calcium endocrinology was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups.Results Research priorities encompass primary hyperparathyroidism, chronic hypoparathyroidism, and rare calcium-phosphate disorders. Key areas include bone as endocrine organ, bone mass acquisition, secondary osteoporosis, and skeletal dysplasias. Special emphasis is placed on cellular senescence, sex-specific differences in disease manifestation, and development of novel diagnostic tools for bone quality assessment.Conclusions This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into metabolic bone disease pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of these disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Endocrinology

ISSN

0804-4643

e-ISSN

1479-683X

Svazek periodika

193

Číslo periodika v rámci svazku

Suppl.2

Stát vydavatele periodika

DK - Dánské království

Počet stran výsledku

12

Strana od-do

"ii23"-"ii34"

Kód UT WoS článku

001595190000001

EID výsledku v databázi Scopus

2-s2.0-105019114852