Micro/nano-structured titanium surfaces modified by NaOH–CaCl2-heat-water treatment: Biomimetic calcium phosphate deposition and hMSCs behavior.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985831%3A_____%2F21%3A00545198" target="_blank" >RIV/67985831:_____/21:00545198 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985858:_____/21:00545198 RIV/44555601:13440/21:43896392 RIV/49777513:23640/21:43962532

Výsledek na webu

<a href="http://hdl.handle.net/11104/0321933" target="_blank" >http://hdl.handle.net/11104/0321933</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.matchemphys.2021.124896" target="_blank" >10.1016/j.matchemphys.2021.124896</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Micro/nano-structured titanium surfaces modified by NaOH–CaCl2-heat-water treatment: Biomimetic calcium phosphate deposition and hMSCs behavior.

Popis výsledku v původním jazyce

The unexplored effect of chemical treatment of laser micro/nanostructured titanium surfaces deserves attention due to broadening our knowledge of surface enhancement of biomimetic synthesis of hydroxyapatite and osseointegration of titanium implants. In this study, NaOH–CaCl2-heat-water treatment of titanium is revisited and used to modify porous laser micro/nanostructured oxidic and flat titanium surfaces which are characterized by XRD, electron microscopy, zeta potential and FTIR and Raman spectroscopy. These surfaces are also assessed for their ability to induce biomimetic Ca phosphate deposition from a simulated body fluid (SBF) and to grow human Mesenchymal stem cells (hMSCs). The treatment of titanium surfaces is shown to involve unreported formation of crystalline CaCO3 and the related interpretation of physicochemical changes of the treated titanium surface in soaked SBF raises doubts about the specific role of an intermediary CaTiO3 in the biomimetic formation of apatite on titanium substrates. We show that the biomimetic formation of Ca phosphate in Tas SBF solution occurs both on the surface and in the bulk solution, it is enhanced on the structured surfaces and is affected by a Ca–O(Ti) layer originating on the pristine and chemical treated flat and micro/nanostructured topographies with different delays. These findings are confronted with the pilot results of in vitro analyses showing that the cell growth, shape and osteogenic differentiation of hMSCs are impeded on the surfaces modified by the NaOH–CaCl2-heat-water treatment.

Název v anglickém jazyce

Micro/nano-structured titanium surfaces modified by NaOH–CaCl2-heat-water treatment: Biomimetic calcium phosphate deposition and hMSCs behavior.

Popis výsledku anglicky

The unexplored effect of chemical treatment of laser micro/nanostructured titanium surfaces deserves attention due to broadening our knowledge of surface enhancement of biomimetic synthesis of hydroxyapatite and osseointegration of titanium implants. In this study, NaOH–CaCl2-heat-water treatment of titanium is revisited and used to modify porous laser micro/nanostructured oxidic and flat titanium surfaces which are characterized by XRD, electron microscopy, zeta potential and FTIR and Raman spectroscopy. These surfaces are also assessed for their ability to induce biomimetic Ca phosphate deposition from a simulated body fluid (SBF) and to grow human Mesenchymal stem cells (hMSCs). The treatment of titanium surfaces is shown to involve unreported formation of crystalline CaCO3 and the related interpretation of physicochemical changes of the treated titanium surface in soaked SBF raises doubts about the specific role of an intermediary CaTiO3 in the biomimetic formation of apatite on titanium substrates. We show that the biomimetic formation of Ca phosphate in Tas SBF solution occurs both on the surface and in the bulk solution, it is enhanced on the structured surfaces and is affected by a Ca–O(Ti) layer originating on the pristine and chemical treated flat and micro/nanostructured topographies with different delays. These findings are confronted with the pilot results of in vitro analyses showing that the cell growth, shape and osteogenic differentiation of hMSCs are impeded on the surfaces modified by the NaOH–CaCl2-heat-water treatment.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20506 - Coating and films

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Materials Chemistry and Physics

ISSN

0254-0584

e-ISSN

1879-3312

Svazek periodika

272

Číslo periodika v rámci svazku

NOV 1

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

16

Strana od-do

124896

Kód UT WoS článku

000682347200003

EID výsledku v databázi Scopus

2-s2.0-85109945890