Markers of Lipid Oxidative Damage in the Exhaled Breath Condensate of Nano TiO2 Production Workers.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985858%3A_____%2F17%3A00470937" target="_blank" >RIV/67985858:_____/17:00470937 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388955:_____/17:00470937 RIV/00216208:11110/17:10361865 RIV/00216208:11510/17:10361865 RIV/60461373:22310/17:43902833 RIV/00064165:_____/17:10361865

Výsledek na webu

<a href="http://dx.doi.org/10.1080/17435390.2016.1262921" target="_blank" >http://dx.doi.org/10.1080/17435390.2016.1262921</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/17435390.2016.1262921" target="_blank" >10.1080/17435390.2016.1262921</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Markers of Lipid Oxidative Damage in the Exhaled Breath Condensate of Nano TiO2 Production Workers.

Popis výsledku v původním jazyce

Nanoscale titanium dioxide (nanoTiO2) is a commercially important nanomaterial. Animal studies have documented lung injury and inflammation, oxidative stress, cytotoxicity and genotoxicity. Yet human health data are scarce and quantitative risk assessments and biomonitoring of exposure are lacking. NanoTiO2 is classified by IARC as a group 2B, possible human carcinogen. In our earlier studies we documented an increase in markers of inflammation, as well as DNA and protein oxidative damage, in exhaled breath condensate (EBC) of workers exposed nanoTiO2. This study focuses on biomarkers of lipid oxidation. Several established lipid oxidative markers (malondialdehyde, 4-hydroxy-trans-hexenal, 4-hydroxy-trans-nonenal, 8-isoProstaglandin F2α and aldehydes C6-C12) were studied in EBC and urine of 34 workers and 45 comparable controls. The median particle number concentration in the production line ranged from 1.98x104 to 2.32x104 particles/cm3 with ∼80% of the particles <100 nm in diameter. Mass concentration varied between 0.40-0.65 mg/m3. All 11 markers of lipid oxidation were elevated in production workers relative to the controls (p < 0.001). A significant dose-dependent association was found between exposure to TiO2 and markers of lipid oxidation in the EBC. These markers were not elevated in the urine samples. Lipid oxidation in the EBC of workers exposed to (nano)TiO2 complements our earlier findings on DNA and protein damage. These results are consistent with the oxidative stress hypothesis and suggest lung injury at the molecular level. Further studies should focus on clinical markers of potential disease progression. EBC has reemerged as a sensitive technique for non-invasive monitoring of workers exposed to engineered nanoparticles.

Název v anglickém jazyce

Markers of Lipid Oxidative Damage in the Exhaled Breath Condensate of Nano TiO2 Production Workers.

Popis výsledku anglicky

Nanoscale titanium dioxide (nanoTiO2) is a commercially important nanomaterial. Animal studies have documented lung injury and inflammation, oxidative stress, cytotoxicity and genotoxicity. Yet human health data are scarce and quantitative risk assessments and biomonitoring of exposure are lacking. NanoTiO2 is classified by IARC as a group 2B, possible human carcinogen. In our earlier studies we documented an increase in markers of inflammation, as well as DNA and protein oxidative damage, in exhaled breath condensate (EBC) of workers exposed nanoTiO2. This study focuses on biomarkers of lipid oxidation. Several established lipid oxidative markers (malondialdehyde, 4-hydroxy-trans-hexenal, 4-hydroxy-trans-nonenal, 8-isoProstaglandin F2α and aldehydes C6-C12) were studied in EBC and urine of 34 workers and 45 comparable controls. The median particle number concentration in the production line ranged from 1.98x104 to 2.32x104 particles/cm3 with ∼80% of the particles <100 nm in diameter. Mass concentration varied between 0.40-0.65 mg/m3. All 11 markers of lipid oxidation were elevated in production workers relative to the controls (p < 0.001). A significant dose-dependent association was found between exposure to TiO2 and markers of lipid oxidation in the EBC. These markers were not elevated in the urine samples. Lipid oxidation in the EBC of workers exposed to (nano)TiO2 complements our earlier findings on DNA and protein damage. These results are consistent with the oxidative stress hypothesis and suggest lung injury at the molecular level. Further studies should focus on clinical markers of potential disease progression. EBC has reemerged as a sensitive technique for non-invasive monitoring of workers exposed to engineered nanoparticles.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30304 - Public and environmental health

Projekt

<a href="/cs/project/GBP503%2F12%2FG147" target="_blank" >GBP503/12/G147: Centrum studií toxických vlastností nanočástic</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nanotoxicology

ISSN

1743-5390

e-ISSN

—

Svazek periodika

11

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

52-63

Kód UT WoS článku

000394718700006

EID výsledku v databázi Scopus

2-s2.0-85003828452