Adaptive Synthesis of Functional Amphiphilic Dendrons as a Novel Approach to Artificial Supramolecular Objects.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985858%3A_____%2F22%3A00553682" target="_blank" >RIV/67985858:_____/22:00553682 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/44555601:13440/22:43896933

Výsledek na webu

<a href="https://www.mdpi.com/1422-0067/23/4/2114" target="_blank" >https://www.mdpi.com/1422-0067/23/4/2114</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms23042114" target="_blank" >10.3390/ijms23042114</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Adaptive Synthesis of Functional Amphiphilic Dendrons as a Novel Approach to Artificial Supramolecular Objects.

Popis výsledku v původním jazyce

Supramolecular structures, such as micelles, liposomes, polymerosomes or dendrimerosomes, are widely studied and used as drug delivery systems. The behavior of amphiphilic building blocks strongly depends on their spatial distribution and shape of polar and nonpolar component. This report is focused on the development of new versatile synthetic protocols for amphiphilic carbosilane dendrons (amp‐CS‐DDNs) capable of self‐assembly to regular micelles and other supramolecular objects. The presented strategy enables the fine modification of amphiphilic structure in several ways and also enables the facile connection of a desired functionality. DLS experiments demonstrated correlations between structural parameters of amp‐CS‐DDNs and the size of formed nanoparticles. For detailed information about the organization and spatial distribution of amp‐CS‐DDNs assemblies, computer simulation models were studied by using molecular dynamics in explicit water.

Název v anglickém jazyce

Adaptive Synthesis of Functional Amphiphilic Dendrons as a Novel Approach to Artificial Supramolecular Objects.

Popis výsledku anglicky

Supramolecular structures, such as micelles, liposomes, polymerosomes or dendrimerosomes, are widely studied and used as drug delivery systems. The behavior of amphiphilic building blocks strongly depends on their spatial distribution and shape of polar and nonpolar component. This report is focused on the development of new versatile synthetic protocols for amphiphilic carbosilane dendrons (amp‐CS‐DDNs) capable of self‐assembly to regular micelles and other supramolecular objects. The presented strategy enables the fine modification of amphiphilic structure in several ways and also enables the facile connection of a desired functionality. DLS experiments demonstrated correlations between structural parameters of amp‐CS‐DDNs and the size of formed nanoparticles. For detailed information about the organization and spatial distribution of amp‐CS‐DDNs assemblies, computer simulation models were studied by using molecular dynamics in explicit water.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10401 - Organic chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Molecular Sciences

ISSN

1422-0067

e-ISSN

1422-0067

Svazek periodika

23

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

17

Strana od-do

2114

Kód UT WoS článku

000775770300001

EID výsledku v databázi Scopus

2-s2.0-85124481199