Zeolite-based chiral ion-exchangers for chromatographic enantioseparations and potential applications in membrane separation processes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985858%3A_____%2F24%3A00588264" target="_blank" >RIV/67985858:_____/24:00588264 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22310/24:43929113 RIV/60461373:22330/24:43929113 RIV/60461373:22340/24:43929113 RIV/00216208:11310/24:10481910

Výsledek na webu

<a href="https://hdl.handle.net/11104/0355202" target="_blank" >https://hdl.handle.net/11104/0355202</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.talanta.2024.126419" target="_blank" >10.1016/j.talanta.2024.126419</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Zeolite-based chiral ion-exchangers for chromatographic enantioseparations and potential applications in membrane separation processes

Popis výsledku v původním jazyce

Chiral resolution of racemic compounds represents an important task in research and development and, most importantly, in the large-scale production of pharmaceuticals. Zeolites, which are already frequently utilized for their unique properties, represent materials that can be used for the development of new chiral stationary phases for liquid chromatography, simulated moving bed or enantioselective membranes. The aim of this study was to modify a series of MWW zeolites by a chiral anion-exchange type selector thereby creating a chiral stationary phase for enantiomeric resolution of acidic compounds. To evaluate the applicability of the prepared chiral stationary phase in liquid chromatography, we used N-protected amino acids as model analytes. First, we tested the new sorbents preferential sorption using N-(3,5-dinitrobenzoyl)leucine. We observed outstanding sorption properties of a zeolite-based sorbent (MCM-36), which were comparable to spherical chromatographic silica. This particular material was subsequently packed into a chromatographic column, which was tested under polar organic mode HPLC conditions facilitating baseline resolution of 5 out of 8 N-protected amino acids. Although the chromatographic performance shows several drawbacks (high backpressure, low column efficiency), it clearly documents the potential of the novel materials in chiral separation. To the best of our knowledge, this is the first example of the preparation of the chiral stationary phase based on MWW zeolites ever.

Název v anglickém jazyce

Zeolite-based chiral ion-exchangers for chromatographic enantioseparations and potential applications in membrane separation processes

Popis výsledku anglicky

Chiral resolution of racemic compounds represents an important task in research and development and, most importantly, in the large-scale production of pharmaceuticals. Zeolites, which are already frequently utilized for their unique properties, represent materials that can be used for the development of new chiral stationary phases for liquid chromatography, simulated moving bed or enantioselective membranes. The aim of this study was to modify a series of MWW zeolites by a chiral anion-exchange type selector thereby creating a chiral stationary phase for enantiomeric resolution of acidic compounds. To evaluate the applicability of the prepared chiral stationary phase in liquid chromatography, we used N-protected amino acids as model analytes. First, we tested the new sorbents preferential sorption using N-(3,5-dinitrobenzoyl)leucine. We observed outstanding sorption properties of a zeolite-based sorbent (MCM-36), which were comparable to spherical chromatographic silica. This particular material was subsequently packed into a chromatographic column, which was tested under polar organic mode HPLC conditions facilitating baseline resolution of 5 out of 8 N-protected amino acids. Although the chromatographic performance shows several drawbacks (high backpressure, low column efficiency), it clearly documents the potential of the novel materials in chiral separation. To the best of our knowledge, this is the first example of the preparation of the chiral stationary phase based on MWW zeolites ever.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20402 - Chemical process engineering

Projekt

<a href="/cs/project/GA23-06152S" target="_blank" >GA23-06152S: Modulární přístup k chirálním membránám pro rozšiřitelnou enantioseparaci racemických léčiv</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Talanta

ISSN

0039-9140

e-ISSN

1873-3573

Svazek periodika

278

Číslo periodika v rámci svazku

OCT 1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

126419

Kód UT WoS článku

001259499400001

EID výsledku v databázi Scopus

2-s2.0-85186115278