Transcriptomics insight into occupational exposure to engineered nanoparticles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985858%3A_____%2F25%3A00637925" target="_blank" >RIV/67985858:_____/25:00637925 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/25:00637925 RIV/68407700:21230/25:00384399 RIV/46747885:24210/25:00013709 RIV/00216208:11110/25:10500061 a 2 dalších

Výsledek na webu

<a href="https://www.tandfonline.com/doi/full/10.1080/17435889.2025.2527020" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/17435889.2025.2527020</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/17435889.2025.2527020" target="_blank" >10.1080/17435889.2025.2527020</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Transcriptomics insight into occupational exposure to engineered nanoparticles

Popis výsledku v původním jazyce

Aim: To investigate the effect of acute (daily) inhalation of nanoparticles (NPs) on the transcriptomic profile of male nanocomposite research workers with a history of long-term exposure (years).nMaterials & methods: Whole genome mRNA and miRNA expression changes were analyzed from blood samples collected before and after machining or welding. Exposure in the work environment was assessed using stationary and personal monitoring.nResults: Following PM0.1 exposure, a significant decrease in the expression of DDIT4 and FKBP5, genes involved in the stress response, was detected in exposed workers. In the Machining group, the DDIT4 expression correlated with the exposure dose. Increased levels of miR30-d-5p and miR-3613-5p (both involved in carcinogenesis) in welders were associated with the NP exposure dose, highlighting their potential suitability as inhalation exposure markers.nConclusion: The results from this pilot transcriptomic analysis (mRNA and miRNA) indicate that exposure to NPs contributes to immune system deregulation and alters the pathways related to cancer. Therefore, the use of protective equipment, as well as obtaining more data by additional research, is highly recommended.

Název v anglickém jazyce

Transcriptomics insight into occupational exposure to engineered nanoparticles

Popis výsledku anglicky

Aim: To investigate the effect of acute (daily) inhalation of nanoparticles (NPs) on the transcriptomic profile of male nanocomposite research workers with a history of long-term exposure (years).nMaterials & methods: Whole genome mRNA and miRNA expression changes were analyzed from blood samples collected before and after machining or welding. Exposure in the work environment was assessed using stationary and personal monitoring.nResults: Following PM0.1 exposure, a significant decrease in the expression of DDIT4 and FKBP5, genes involved in the stress response, was detected in exposed workers. In the Machining group, the DDIT4 expression correlated with the exposure dose. Increased levels of miR30-d-5p and miR-3613-5p (both involved in carcinogenesis) in welders were associated with the NP exposure dose, highlighting their potential suitability as inhalation exposure markers.nConclusion: The results from this pilot transcriptomic analysis (mRNA and miRNA) indicate that exposure to NPs contributes to immune system deregulation and alters the pathways related to cancer. Therefore, the use of protective equipment, as well as obtaining more data by additional research, is highly recommended.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30305 - Occupational health

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nanomedicine

ISSN

1743-5889

e-ISSN

1748-6963

Svazek periodika

20

Číslo periodika v rámci svazku

14

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

15

Strana od-do

1713-1727

Kód UT WoS článku

001522161200001

EID výsledku v databázi Scopus

2-s2.0-105009989330