Influence of polyacrylic acid nanoparticles on the elastic properties of RBCs membranes in patients with diabetes mellitus type 2
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985874%3A_____%2F15%3A00453579" target="_blank" >RIV/67985874:_____/15:00453579 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Influence of polyacrylic acid nanoparticles on the elastic properties of RBCs membranes in patients with diabetes mellitus type 2
Popis výsledku v původním jazyce
The influence of polyacrylic acid (PAA) derived nanoparticles, a star shaped macromolecules with/nhydrodynamic radius of 14 nm, on the structure and mechanical properties of red blood cells (RBCs) membranes in/npatients with diabetes mellitus type 2 by AFM method has been studied. Their behavior has been compared to that/nof linear PAAs with different degrees of polymerization. Significant changes in the structure of RBCs membranes/ndid not occur and traces of polymer chains or nanoparticles were not found. It was shown, that changes of the/nelasticity modulus were observed after cells incubated in the presence of linear PAA with Mn =20000 Da and/n225000 Da, due to the interaction of polymer chains with the components of the cell membrane. The star shaped/nNPs with Mn = 57000 Da lead to the smallest changes in the structure and properties cells membrane. Thus, these/nNPs can be recommended for drug delivery applications.
Název v anglickém jazyce
Influence of polyacrylic acid nanoparticles on the elastic properties of RBCs membranes in patients with diabetes mellitus type 2
Popis výsledku anglicky
The influence of polyacrylic acid (PAA) derived nanoparticles, a star shaped macromolecules with/nhydrodynamic radius of 14 nm, on the structure and mechanical properties of red blood cells (RBCs) membranes in/npatients with diabetes mellitus type 2 by AFM method has been studied. Their behavior has been compared to that/nof linear PAAs with different degrees of polymerization. Significant changes in the structure of RBCs membranes/ndid not occur and traces of polymer chains or nanoparticles were not found. It was shown, that changes of the/nelasticity modulus were observed after cells incubated in the presence of linear PAA with Mn =20000 Da and/n225000 Da, due to the interaction of polymer chains with the components of the cell membrane. The star shaped/nNPs with Mn = 57000 Da lead to the smallest changes in the structure and properties cells membrane. Thus, these/nNPs can be recommended for drug delivery applications.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
BK - Mechanika tekutin
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Series on biomechanics
ISSN
1313-2458
e-ISSN
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Svazek periodika
29
Číslo periodika v rámci svazku
4
Stát vydavatele periodika
BG - Bulharská republika
Počet stran výsledku
8
Strana od-do
12-19
Kód UT WoS článku
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EID výsledku v databázi Scopus
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