Mixing characteristics of unbaffled bioreactor with levitating radial impeller

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985874%3A_____%2F23%3A00571291" target="_blank" >RIV/67985874:_____/23:00571291 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22340/23:43926330

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0009250923003573?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0009250923003573?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ces.2023.118801" target="_blank" >10.1016/j.ces.2023.118801</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mixing characteristics of unbaffled bioreactor with levitating radial impeller

Popis výsledku v původním jazyce

In the pharmaceutical and biotechnology industries, ensuring the cleanliness and sterility of the process environment is of utmost importance. To achieve this, some commercially available bioreactors are designed as unbaffled vessels with an eccentrically mounted, magnetically driven impeller. Contrary to the well-studied nature of turbulent mixing in standard baffled reactors, the mixing performance in such atypical vessels has not been thoroughly explored in the literature. This study aims to fill the knowledge gap on this subject by focusing on the mixing time in an atypical reactor using two experimental techniques, conductometry, and decolorization. The conductometric results demonstrate that the mixing times of the atypical reactor remain similar to the baffled configurations up to a height-to-diameter ratio of 1.2. Above this ratio, mixing times rapidly increase. Based on the experimental results, correlations for the design of standard and atypical vessels with small radial impellers have been proposed, also concerning the liquid height. Furthermore, the decolorization experiments in the atypical reactor revealed the formation of the segregated vortex region, in which the homogenization process takes up to four times longer period than is required for the remainder of the reactor volume. The impact of this vortex formation on the vessel mixing characteristics is discussed.

Název v anglickém jazyce

Mixing characteristics of unbaffled bioreactor with levitating radial impeller

Popis výsledku anglicky

In the pharmaceutical and biotechnology industries, ensuring the cleanliness and sterility of the process environment is of utmost importance. To achieve this, some commercially available bioreactors are designed as unbaffled vessels with an eccentrically mounted, magnetically driven impeller. Contrary to the well-studied nature of turbulent mixing in standard baffled reactors, the mixing performance in such atypical vessels has not been thoroughly explored in the literature. This study aims to fill the knowledge gap on this subject by focusing on the mixing time in an atypical reactor using two experimental techniques, conductometry, and decolorization. The conductometric results demonstrate that the mixing times of the atypical reactor remain similar to the baffled configurations up to a height-to-diameter ratio of 1.2. Above this ratio, mixing times rapidly increase. Based on the experimental results, correlations for the design of standard and atypical vessels with small radial impellers have been proposed, also concerning the liquid height. Furthermore, the decolorization experiments in the atypical reactor revealed the formation of the segregated vortex region, in which the homogenization process takes up to four times longer period than is required for the remainder of the reactor volume. The impact of this vortex formation on the vessel mixing characteristics is discussed.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20401 - Chemical engineering (plants, products)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemical Engineering Science

ISSN

0009-2509

e-ISSN

1873-4405

Svazek periodika

276

Číslo periodika v rámci svazku

July

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

118801

Kód UT WoS článku

000993813100001

EID výsledku v databázi Scopus

2-s2.0-85153963375