Free-Blockage Mesoporous Silica Nanoparticles Loaded with Cerium Oxide as ROS-Responsive and ROS-Scavenging Nanomedicine

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985891%3A_____%2F22%3A00564327" target="_blank" >RIV/67985891:_____/22:00564327 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11320/22:10455645

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1002/adfm.202208316" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/adfm.202208316</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/adfm.202208316" target="_blank" >10.1002/adfm.202208316</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Free-Blockage Mesoporous Silica Nanoparticles Loaded with Cerium Oxide as ROS-Responsive and ROS-Scavenging Nanomedicine

Popis výsledku v původním jazyce

Mesoporous silica nanoparticles (MSNs) with reactive oxygen species (ROS)-responsive nanogate as drug delivery platforms are extensively investigated for biomedical applications. However, the physical blockages used to control the cargo release are often limited by their poor sealing ability and low biocompatibility. Herein, a design of free-blockage MSNs with methylthiopropyl units is proposed as the ROS-responsive switch. Four synthetic routes are compared with different precursors through either co-condensation or grafting methods to achieve the methylthio-functionalized MSNs. The quantity, localization, and chemical structure of the functional units, as well as the mesoporous structure of the silica can be tuned by optimizing the synthetic pathways to obtain desired final products. The ROS-responsive methylthiopropyl groups can be oxidized to sulfoxides in response to the presence of H2O2, leading to the hydrophobic/hydrophilic conversion of the MSNs. As a proof-of-concept design, ultrasmall cerium oxide nanoparticles are encapsulated into the functionalized MSNs and released out within 10 min scavenging more than 80% of the H2O2 in an ROS-rich environment. This study provides a novel design of a free-blockage ROS-controlled release system loaded with ROS-scavenging nanoparticles for the future application of targeted drug delivery systems combined with antioxidant therapy.

Název v anglickém jazyce

Free-Blockage Mesoporous Silica Nanoparticles Loaded with Cerium Oxide as ROS-Responsive and ROS-Scavenging Nanomedicine

Popis výsledku anglicky

Mesoporous silica nanoparticles (MSNs) with reactive oxygen species (ROS)-responsive nanogate as drug delivery platforms are extensively investigated for biomedical applications. However, the physical blockages used to control the cargo release are often limited by their poor sealing ability and low biocompatibility. Herein, a design of free-blockage MSNs with methylthiopropyl units is proposed as the ROS-responsive switch. Four synthetic routes are compared with different precursors through either co-condensation or grafting methods to achieve the methylthio-functionalized MSNs. The quantity, localization, and chemical structure of the functional units, as well as the mesoporous structure of the silica can be tuned by optimizing the synthetic pathways to obtain desired final products. The ROS-responsive methylthiopropyl groups can be oxidized to sulfoxides in response to the presence of H2O2, leading to the hydrophobic/hydrophilic conversion of the MSNs. As a proof-of-concept design, ultrasmall cerium oxide nanoparticles are encapsulated into the functionalized MSNs and released out within 10 min scavenging more than 80% of the H2O2 in an ROS-rich environment. This study provides a novel design of a free-blockage ROS-controlled release system loaded with ROS-scavenging nanoparticles for the future application of targeted drug delivery systems combined with antioxidant therapy.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30107 - Medicinal chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Advanced Functional Materials

ISSN

1616-301X

e-ISSN

1616-3028

Svazek periodika

32

Číslo periodika v rámci svazku

46

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

21

Strana od-do

2208316

Kód UT WoS článku

000860643300001

EID výsledku v databázi Scopus

2-s2.0-85138733240