Rozdílné schopnosti steroidního (ICI 182 780) a nesteroidního (EM-800) antiestrogenu inhibitovat růst reprodukčních orgánů samců a samic myší

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F05%3A00029376" target="_blank" >RIV/67985904:_____/05:00029376 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Contrasting ability of steroidal (ICI 182 780) and non-steroidal (EM-800) antiestrogens to inhibit reproductive organ growth in male and female mice

Popis výsledku v původním jazyce

The changes in mammary, uterine and seminal vesicle growth were intended to identify the in vivo activity of estrogen antagonists. Using the combinations of hormone agonist and antagonist, we tested and compared four models systems, the young intact andadult gonadectomized male and female mice. Steroidal antiestrogen (ICI) always behaved as an antiestrogen: ICI alone or in combination with estradiol (E) or progesterone (Prog) decreased mammary and uterine growth in prepubertal and adult ovariectomized(OV-X) females and decreased mammary growth in prepubertal and adult castrated males treated with E. In prepubertal males ICI alone or in combination with Prog or E also increased seminal vesicle weights. Nonsteroidal antiestrogen EM-800 (EM) alone had no effect on mammary and uterine growth in prepubertal females, and in adult OV-X females uterine growth was even stimulated by EM alone, and a combination of EM plus Prog stimulated not only uterine growth but also mam,ary growth.

Název v anglickém jazyce

Contrasting ability of steroidal (ICI 182 780) and non-steroidal (EM-800) antiestrogens to inhibit reproductive organ growth in male and female mice

Popis výsledku anglicky

The changes in mammary, uterine and seminal vesicle growth were intended to identify the in vivo activity of estrogen antagonists. Using the combinations of hormone agonist and antagonist, we tested and compared four models systems, the young intact andadult gonadectomized male and female mice. Steroidal antiestrogen (ICI) always behaved as an antiestrogen: ICI alone or in combination with estradiol (E) or progesterone (Prog) decreased mammary and uterine growth in prepubertal and adult ovariectomized(OV-X) females and decreased mammary growth in prepubertal and adult castrated males treated with E. In prepubertal males ICI alone or in combination with Prog or E also increased seminal vesicle weights. Nonsteroidal antiestrogen EM-800 (EM) alone had no effect on mammary and uterine growth in prepubertal females, and in adult OV-X females uterine growth was even stimulated by EM alone, and a combination of EM plus Prog stimulated not only uterine growth but also mam,ary growth.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

<a href="/cs/project/IBS5045302" target="_blank" >IBS5045302: Detekce syntetických a environmentálních xenobiotik narušujících endokrinní systém zvířat a lidí</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta veterinaria Brno

ISSN

0001-7213

e-ISSN

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Svazek periodika

74

Číslo periodika v rámci svazku

-

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

9

Strana od-do

533-541

Kód UT WoS článku

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EID výsledku v databázi Scopus

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