Myší modely zubních abnormalit

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F08%3A00312886" target="_blank" >RIV/67985904:_____/08:00312886 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Mouse models of tooth abnormalities

Popis výsledku v původním jazyce

Tooth number is abnormal in about 20% of the human population.The most common defect is agenesis of the third molars, followed by loss of the lateral incisors and loss of the second premolars.Tooth loss appears as both a feature of multi-organ syndromesand as a non-syndromic isolated character.Apart from tooth number, abnormalities are also observed in tooth size, shape, and structure.Many of the genes that underlie dental defects have been identified,and several mouse models have been created to allowfunctional studies to understand,in greater detail,role of particular genes in tooth development.Ability to manipulate the mouse embryo using explant culture and genome targeting provides a wealth of information that ultimately may pave the way for better diagnostics,treatment or even cures for human dental disorders.This review aims to summarize recent knowledge obtained in mouse models,which can be used to gain a better understanding of the mol. basis of human dental abnormalities.

Název v anglickém jazyce

Mouse models of tooth abnormalities

Popis výsledku anglicky

Tooth number is abnormal in about 20% of the human population.The most common defect is agenesis of the third molars, followed by loss of the lateral incisors and loss of the second premolars.Tooth loss appears as both a feature of multi-organ syndromesand as a non-syndromic isolated character.Apart from tooth number, abnormalities are also observed in tooth size, shape, and structure.Many of the genes that underlie dental defects have been identified,and several mouse models have been created to allowfunctional studies to understand,in greater detail,role of particular genes in tooth development.Ability to manipulate the mouse embryo using explant culture and genome targeting provides a wealth of information that ultimately may pave the way for better diagnostics,treatment or even cures for human dental disorders.This review aims to summarize recent knowledge obtained in mouse models,which can be used to gain a better understanding of the mol. basis of human dental abnormalities.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FF - ORL, oftalmologie, stomatologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Oral Sciences

ISSN

0909-8836

e-ISSN

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Svazek periodika

116

Číslo periodika v rámci svazku

-

Stát vydavatele periodika

DK - Dánské království

Počet stran výsledku

10

Strana od-do

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Kód UT WoS článku

000252207000001

EID výsledku v databázi Scopus

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