Ribonucleases, nucleases and antiangiogenins in antiproliferative activities

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F11%3A00373351" target="_blank" >RIV/67985904:_____/11:00373351 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.2174/157436211797483921" target="_blank" >http://dx.doi.org/10.2174/157436211797483921</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/157436211797483921" target="_blank" >10.2174/157436211797483921</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Ribonucleases, nucleases and antiangiogenins in antiproliferative activities

Popis výsledku v původním jazyce

The animal ribonucleases and plant nucleases are selective cytotoxic enzymes with several biological activities inclusively also with antitumorous effects. The first attention from animal researches is dated to 1938 year, meanwhile plant enzyme investigators awoke their attention in last time. The bovine pancreatic ribonuclease, after the first structurally studies, allured very soon the peoples with functionally interests. The results of studies directed to antitumor effect were firstly very weak. Thelatter isolated bovine seminal ribonuclease was more effective from this aspect. Also human pancreatic ribonuclease stimulated interest about its antitumor activity what was realized by its dimerization and other molecular studies. Ribonuclease inhibitors have been very limited substances in the cytotoxicity of antitumor effectivity. On the other side a conjugation of cytostatic enzymes with polymers enhanced the antitumor activity of them and lowered their toxicity.

Název v anglickém jazyce

Ribonucleases, nucleases and antiangiogenins in antiproliferative activities

Popis výsledku anglicky

The animal ribonucleases and plant nucleases are selective cytotoxic enzymes with several biological activities inclusively also with antitumorous effects. The first attention from animal researches is dated to 1938 year, meanwhile plant enzyme investigators awoke their attention in last time. The bovine pancreatic ribonuclease, after the first structurally studies, allured very soon the peoples with functionally interests. The results of studies directed to antitumor effect were firstly very weak. Thelatter isolated bovine seminal ribonuclease was more effective from this aspect. Also human pancreatic ribonuclease stimulated interest about its antitumor activity what was realized by its dimerization and other molecular studies. Ribonuclease inhibitors have been very limited substances in the cytotoxicity of antitumor effectivity. On the other side a conjugation of cytostatic enzymes with polymers enhanced the antitumor activity of them and lowered their toxicity.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Signal Transduction Therapy

ISSN

1574-3624

e-ISSN

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Svazek periodika

6

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

AE - Spojené arabské emiráty

Počet stran výsledku

20

Strana od-do

363-382

Kód UT WoS článku

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EID výsledku v databázi Scopus

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