Molecular mechanisms of neuropathological changes in Alzheimer's disease: a review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F13%3A00425399" target="_blank" >RIV/67985904:_____/13:00425399 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14310/13:00065652 RIV/61988987:17110/13:A14019VF

Výsledek na webu

<a href="http://dx.doi.org/10.5114/fn.2013.34190" target="_blank" >http://dx.doi.org/10.5114/fn.2013.34190</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5114/fn.2013.34190" target="_blank" >10.5114/fn.2013.34190</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Molecular mechanisms of neuropathological changes in Alzheimer's disease: a review

Popis výsledku v původním jazyce

More than 100 years after description of Alzheimer's disease (AD), two major pathological processes observed already by Alois Alzheimer, remain as the main explanation of the pathogenesis of Alzheimer's disease. Important molecular interactions leading to AD neuropathology were described in amyloid cascade and in tau protein function. No clinical trials with novel therapies based on amyloid cascade and tau protein hypotheses have been successful. The main aim of recent research is focused on the question what is primary mechanism leading to the molecular development of AD pathology Promising explanation of triggering mechanism can be seen in vascular pathology that have direct influence on the development of pathological processes typical for Alzheimerdisease. Novel insight into a number of cellular signaling mechanisms, as well as mitochondrial function in Alzheimer disease could also bring explanations of initial processes leading to the development of this pathology.

Název v anglickém jazyce

Molecular mechanisms of neuropathological changes in Alzheimer's disease: a review

Popis výsledku anglicky

More than 100 years after description of Alzheimer's disease (AD), two major pathological processes observed already by Alois Alzheimer, remain as the main explanation of the pathogenesis of Alzheimer's disease. Important molecular interactions leading to AD neuropathology were described in amyloid cascade and in tau protein function. No clinical trials with novel therapies based on amyloid cascade and tau protein hypotheses have been successful. The main aim of recent research is focused on the question what is primary mechanism leading to the molecular development of AD pathology Promising explanation of triggering mechanism can be seen in vascular pathology that have direct influence on the development of pathological processes typical for Alzheimerdisease. Novel insight into a number of cellular signaling mechanisms, as well as mitochondrial function in Alzheimer disease could also bring explanations of initial processes leading to the development of this pathology.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/NT11152" target="_blank" >NT11152: Epidemiologie a genetika Alzheimerovy choroby</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Folia Neuropathologica

ISSN

1641-4640

e-ISSN

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Svazek periodika

51

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

9

Strana od-do

1-9

Kód UT WoS článku

000317316400001

EID výsledku v databázi Scopus

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