A comparison of two endoscopic closures: over-the-scope clip (OTSC) versus KING closure (endoloop plus clips) in a randomized long-term experimental study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F16%3A00469025" target="_blank" >RIV/67985904:_____/16:00469025 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/16:10331854 RIV/00023001:_____/16:00060101

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00464-016-4831-z" target="_blank" >http://dx.doi.org/10.1007/s00464-016-4831-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00464-016-4831-z" target="_blank" >10.1007/s00464-016-4831-z</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A comparison of two endoscopic closures: over-the-scope clip (OTSC) versus KING closure (endoloop plus clips) in a randomized long-term experimental study

Popis výsledku v původním jazyce

Both over-the-scope clip (OTSC) and KING (endoloop + clips) closures provide reliable and safe full-thickness endoscopic closure. Nevertheless, OTSC clip demonstrated significantly inferior histological healing in the short-term follow-up. nTo compare OTSC versus KING closure of a perforation with regard to long-term effectiveness and macroscopic and histological quality of healing. nWe performed a randomized experimental study with 16 mini-pigs (mean weight 43.2 +/- 11.2 kg). A standardized perforation was performed on the anterior sigmoid wall. KING closure (n = 8) was attained by approximation of an endoloop fixed to the margins of a perforation with endoclips. OTSC closure (n = 8) was performed by deploying OTSC (OVESCO) over the defect. Pigs underwent a control sigmoidoscopy 8 months after the closure to assess the macroscopic quality of healing. Then, autopsy was performed and the rectosigmoid was sent for histopathological assessment. nAll closures were completed successfully without air leaks. The duration of closure was similar in both techniques (OTSC 17.8 +/- 7.6 min vs. KING 19.6 +/- 8.8 min). At autopsy, all KING closures (100 %) were healed with a flat scar without signs of leakage. Microscopically, no inflammatory changes were observed after KING closure. In the OTSC group, microscopic ulcers were present in two pigs (25 %), cryptal abscesses in three pigs (38 %) and significant neutrophil accumulation in all eight pigs (P < 0.01). Giant cell granulomas, dysplasia or abundant scarification was not observed in either group.nBoth OTSC and KING closures offer a long-term reliable seal of a gastrointestinal perforation without stenosis or fistulas. KING closure provides long-term histologically superior healing.

Název v anglickém jazyce

A comparison of two endoscopic closures: over-the-scope clip (OTSC) versus KING closure (endoloop plus clips) in a randomized long-term experimental study

Popis výsledku anglicky

Both over-the-scope clip (OTSC) and KING (endoloop + clips) closures provide reliable and safe full-thickness endoscopic closure. Nevertheless, OTSC clip demonstrated significantly inferior histological healing in the short-term follow-up. nTo compare OTSC versus KING closure of a perforation with regard to long-term effectiveness and macroscopic and histological quality of healing. nWe performed a randomized experimental study with 16 mini-pigs (mean weight 43.2 +/- 11.2 kg). A standardized perforation was performed on the anterior sigmoid wall. KING closure (n = 8) was attained by approximation of an endoloop fixed to the margins of a perforation with endoclips. OTSC closure (n = 8) was performed by deploying OTSC (OVESCO) over the defect. Pigs underwent a control sigmoidoscopy 8 months after the closure to assess the macroscopic quality of healing. Then, autopsy was performed and the rectosigmoid was sent for histopathological assessment. nAll closures were completed successfully without air leaks. The duration of closure was similar in both techniques (OTSC 17.8 +/- 7.6 min vs. KING 19.6 +/- 8.8 min). At autopsy, all KING closures (100 %) were healed with a flat scar without signs of leakage. Microscopically, no inflammatory changes were observed after KING closure. In the OTSC group, microscopic ulcers were present in two pigs (25 %), cryptal abscesses in three pigs (38 %) and significant neutrophil accumulation in all eight pigs (P < 0.01). Giant cell granulomas, dysplasia or abundant scarification was not observed in either group.nBoth OTSC and KING closures offer a long-term reliable seal of a gastrointestinal perforation without stenosis or fistulas. KING closure provides long-term histologically superior healing.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FJ - Chirurgie včetně transplantologie

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Surgical Endoscopy and Other Interventional Techniques

ISSN

0930-2794

e-ISSN

—

Svazek periodika

30

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

4910-4916

Kód UT WoS článku

000387225600028

EID výsledku v databázi Scopus

2-s2.0-84960102261