Porcine Model of Huntington´s Disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F17%3A00483018" target="_blank" >RIV/67985904:_____/17:00483018 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.intechopen.com/books/huntington-s-disease-molecular-pathogenesis-and-current-models/porcine-model-of-huntington-s-disease" target="_blank" >https://www.intechopen.com/books/huntington-s-disease-molecular-pathogenesis-and-current-models/porcine-model-of-huntington-s-disease</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5772/66353" target="_blank" >10.5772/66353</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Porcine Model of Huntington´s Disease

Popis výsledku v původním jazyce

At present, we are probably the only research facility to be breeding transgenic Huntington's disease minipigs (TgHD). These minipigs express N‐terminal part of human mutated huntingtin including 124Q under the control of human huntingtin promoter. The founder animal, born in 2009, gave birth to four subsequent generations with an equal contribution of wild‐type (WT) and transgenic (TgHD) piglets in all litters. We take different approaches, some of which are unique for large animal models, to study the phenotype development comparing WT and TgHD siblings. In this chapter, we review these approaches and the phenotype progression in the minipigs. Additionally, we outline perspectives in generation of new models using novel methodology and the potential of pig models in preclinical HD studies.

Název v anglickém jazyce

Porcine Model of Huntington´s Disease

Popis výsledku anglicky

At present, we are probably the only research facility to be breeding transgenic Huntington's disease minipigs (TgHD). These minipigs express N‐terminal part of human mutated huntingtin including 124Q under the control of human huntingtin promoter. The founder animal, born in 2009, gave birth to four subsequent generations with an equal contribution of wild‐type (WT) and transgenic (TgHD) piglets in all litters. We take different approaches, some of which are unique for large animal models, to study the phenotype development comparing WT and TgHD siblings. In this chapter, we review these approaches and the phenotype progression in the minipigs. Additionally, we outline perspectives in generation of new models using novel methodology and the potential of pig models in preclinical HD studies.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

30403 - Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])

Projekt

<a href="/cs/project/LO1609" target="_blank" >LO1609: Modely závažných lidských onemocnění: Traumatické poškození míchy, Huntingtonova choroba, melanom a neplodnost</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Huntington´s Disease - Molecular Pathogenesis and Current Models

ISBN

978-953-51-3050-5

Počet stran výsledku

20

Strana od-do

75-94

Počet stran knihy

150

Název nakladatele

Intech

Místo vydání

London

Kód UT WoS kapitoly

—