Potential markers for early diagnostics of Colorectal cancer and Inflammatory bowel disease in humans : intestinal microorganisms and immune system (teammates or rivals)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F17%3A00483861" target="_blank" >RIV/67985904:_____/17:00483861 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.24870/cjb.2017-000109" target="_blank" >http://dx.doi.org/10.24870/cjb.2017-000109</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.24870/cjb.2017-000109" target="_blank" >10.24870/cjb.2017-000109</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Potential markers for early diagnostics of Colorectal cancer and Inflammatory bowel disease in humans : intestinal microorganisms and immune system (teammates or rivals)

Popis výsledku v původním jazyce

Chronic inflammation of the bowel is the characteristic of Inflammatory bowel diseases including Ulcerative colitis and Crohn’s disease. The incidence of Inflammatory bowel disease (IBD) in Western Europe is 14/100,000 of inhabitants. Duration and severity of inflammation increases the risk of Colorectal cancer (CRC) development by about 60% in IBD patients. CRC is the 3rd most common type of tumor in Western population. Every year, more than one million new cases are diagnosed with more than 600,000 deaths.nThe early detection of CRC, originating from any part of the colon-rectum, is desirable because it can be cured surgically if diagnosed timely. Identification of new early markers for IBD and CRC is very important.nThis review deals with the searching and identification of possibly new early markers for the above mentioned pathologies. We have focused on intestinal microorganisms (changes in qualitative and quantitative composition of microbiome, selection of candidate microorganisms) and immune system markers (cytokines, chemokines, nuclear factor kB, Toll-like receptors and Receptor for Advanced Glycation End Products).

Název v anglickém jazyce

Potential markers for early diagnostics of Colorectal cancer and Inflammatory bowel disease in humans : intestinal microorganisms and immune system (teammates or rivals)

Popis výsledku anglicky

Chronic inflammation of the bowel is the characteristic of Inflammatory bowel diseases including Ulcerative colitis and Crohn’s disease. The incidence of Inflammatory bowel disease (IBD) in Western Europe is 14/100,000 of inhabitants. Duration and severity of inflammation increases the risk of Colorectal cancer (CRC) development by about 60% in IBD patients. CRC is the 3rd most common type of tumor in Western population. Every year, more than one million new cases are diagnosed with more than 600,000 deaths.nThe early detection of CRC, originating from any part of the colon-rectum, is desirable because it can be cured surgically if diagnosed timely. Identification of new early markers for IBD and CRC is very important.nThis review deals with the searching and identification of possibly new early markers for the above mentioned pathologies. We have focused on intestinal microorganisms (changes in qualitative and quantitative composition of microbiome, selection of candidate microorganisms) and immune system markers (cytokines, chemokines, nuclear factor kB, Toll-like receptors and Receptor for Advanced Glycation End Products).

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

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OECD FORD obor

30102 - Immunology

Projekt

<a href="/cs/project/LO1609" target="_blank" >LO1609: Modely závažných lidských onemocnění: Traumatické poškození míchy, Huntingtonova choroba, melanom a neplodnost</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Canadian Journal of Biotechnology

ISSN

2560-8304

e-ISSN

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Svazek periodika

1

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CA - Kanada

Počet stran výsledku

6

Strana od-do

59-64

Kód UT WoS článku

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EID výsledku v databázi Scopus

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