BATTERY OF TESTS ASSESSED TO MONITOR MOTOR AND COGNITIVE FUNCTIONS OF TRANSGENIC HUNTINGTON'S DISEASE MINIPIG MODEL

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F18%3A00498968" target="_blank" >RIV/67985904:_____/18:00498968 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

BATTERY OF TESTS ASSESSED TO MONITOR MOTOR AND COGNITIVE FUNCTIONS OF TRANSGENIC HUNTINGTON'S DISEASE MINIPIG MODEL

Popis výsledku v původním jazyce

Hunting for the cure for Huntington´s disease (HD) requires extended pre-clinical studies to screen the safety, tolerability and efficacy of the potential therapeutic treatments. Therefore, the large animal models were developed for translational research to human studies. The battery of tests was designed for monitoring of phenotype similarity of the transgenic HD minipig model with HD patients.nMotor and cognitive functions were monitored in the group of transgenic (tgHD) and wild-type (wt) minipigs in different ages in the 3 following years.nThe results showed differences between tgHD and wt animals. The sex-related differences were observed in performance of the tests. The motor and cognitive functions deteriorated with ageing. TgHD animals have started to lose their weight from the age of 4 years.nThe data showed that the tests are safe and perspective for longitudinal studies. Moreover, tests can discern differences between tgHD and wt animals what enables to assess safety and efficacy of potential HD treatments in pre-clinical studies prior to human clinical trials.n

Název v anglickém jazyce

BATTERY OF TESTS ASSESSED TO MONITOR MOTOR AND COGNITIVE FUNCTIONS OF TRANSGENIC HUNTINGTON'S DISEASE MINIPIG MODEL

Popis výsledku anglicky

Hunting for the cure for Huntington´s disease (HD) requires extended pre-clinical studies to screen the safety, tolerability and efficacy of the potential therapeutic treatments. Therefore, the large animal models were developed for translational research to human studies. The battery of tests was designed for monitoring of phenotype similarity of the transgenic HD minipig model with HD patients.nMotor and cognitive functions were monitored in the group of transgenic (tgHD) and wild-type (wt) minipigs in different ages in the 3 following years.nThe results showed differences between tgHD and wt animals. The sex-related differences were observed in performance of the tests. The motor and cognitive functions deteriorated with ageing. TgHD animals have started to lose their weight from the age of 4 years.nThe data showed that the tests are safe and perspective for longitudinal studies. Moreover, tests can discern differences between tgHD and wt animals what enables to assess safety and efficacy of potential HD treatments in pre-clinical studies prior to human clinical trials.n

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/LO1609" target="_blank" >LO1609: Modely závažných lidských onemocnění: Traumatické poškození míchy, Huntingtonova choroba, melanom a neplodnost</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů