Revitalising the rudimentary replacement dentition in the mouse

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F19%3A00503702" target="_blank" >RIV/67985904:_____/19:00503702 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/19:00517901 RIV/00216224:14310/19:00109295 RIV/68378041:_____/19:00503702

Výsledek na webu

<a href="https://dev.biologists.org/content/146/3/dev171363" target="_blank" >https://dev.biologists.org/content/146/3/dev171363</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1242/dev.171363" target="_blank" >10.1242/dev.171363</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Revitalising the rudimentary replacement dentition in the mouse

Popis výsledku v původním jazyce

Most mammals have two sets of teeth (diphyodont) - a deciduous dentition replaced by a permanent dentition, however, the mouse possesses only one tooth generation (monophyodont). In diphyodonts, the replacement tooth forms on the lingual side of the first tooth from the successional dental lamina. This lamina expresses the stem/progenitor marker Sox2 and has activated Wnt/beta-catenin signalling at its tip. Although the mouse does not replace its teeth, a transient rudimentary successional dental lamina (RSDL) still forms during development. The mouse RSDL houses Sox2-positive cells, but no Wnt/beta-catenin signalling. Here, we show that stabilising Wnt/beta-catenin signalling in the RSDL in the mouse leads to proliferation of the RSDL and formation of lingually positioned teeth. Although Sox2 has been shown to repress Wnt activity, overexpression of Wnts leads to a downregulation of Sox2, suggesting a negative-feedback loop in the tooth. In the mouse, the first tooth represses the formation of the replacement, and isolation of the RSDL is sufficient to induce formation of a new tooth germ. Our data highlight key mechanisms that may have influenced the evolution of replacement teeth.

Název v anglickém jazyce

Revitalising the rudimentary replacement dentition in the mouse

Popis výsledku anglicky

Most mammals have two sets of teeth (diphyodont) - a deciduous dentition replaced by a permanent dentition, however, the mouse possesses only one tooth generation (monophyodont). In diphyodonts, the replacement tooth forms on the lingual side of the first tooth from the successional dental lamina. This lamina expresses the stem/progenitor marker Sox2 and has activated Wnt/beta-catenin signalling at its tip. Although the mouse does not replace its teeth, a transient rudimentary successional dental lamina (RSDL) still forms during development. The mouse RSDL houses Sox2-positive cells, but no Wnt/beta-catenin signalling. Here, we show that stabilising Wnt/beta-catenin signalling in the RSDL in the mouse leads to proliferation of the RSDL and formation of lingually positioned teeth. Although Sox2 has been shown to repress Wnt activity, overexpression of Wnts leads to a downregulation of Sox2, suggesting a negative-feedback loop in the tooth. In the mouse, the first tooth represses the formation of the replacement, and isolation of the RSDL is sufficient to induce formation of a new tooth germ. Our data highlight key mechanisms that may have influenced the evolution of replacement teeth.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10605 - Developmental biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Development

ISSN

0950-1991

e-ISSN

—

Svazek periodika

146

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

UNSP dev171363

Kód UT WoS článku

000458841100014

EID výsledku v databázi Scopus

2-s2.0-85061226297