Double-strand DNA breaks response and Huntington´s disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F20%3A00536494" target="_blank" >RIV/67985904:_____/20:00536494 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Double-strand DNA breaks response and Huntington´s disease

Popis výsledku v původním jazyce

Double-strand DNA breaks (DSBs) are considered as the most harmful DNA lesions, as only one unrepaired DSB is sufficient to trigger chromosomal rearrangements, senescence, or cell death. In recent years, it was proposed that alterations in response to DSBs could contribute to pathology of neurodegenerative diseases, including Huntington's disease. Huntington's disease is a neurodegenerative disorder caused by the expansion of CAG trinucleotide repeats in the huntingtin gene giving rise to mutated form of huntingtin protein (mHTT). Recent findings suggest that presence of mHTT may affect one type of the double-strand DNA breaks repair, the non-homologous end joining. It is suggested that impairment of DSBs repair occurs long before clinical diagnostic of Huntington's disease.

Název v anglickém jazyce

Double-strand DNA breaks response and Huntington´s disease

Popis výsledku anglicky

Double-strand DNA breaks (DSBs) are considered as the most harmful DNA lesions, as only one unrepaired DSB is sufficient to trigger chromosomal rearrangements, senescence, or cell death. In recent years, it was proposed that alterations in response to DSBs could contribute to pathology of neurodegenerative diseases, including Huntington's disease. Huntington's disease is a neurodegenerative disorder caused by the expansion of CAG trinucleotide repeats in the huntingtin gene giving rise to mutated form of huntingtin protein (mHTT). Recent findings suggest that presence of mHTT may affect one type of the double-strand DNA breaks repair, the non-homologous end joining. It is suggested that impairment of DSBs repair occurs long before clinical diagnostic of Huntington's disease.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

10601 - Cell biology

Projekt

<a href="/cs/project/LO1609" target="_blank" >LO1609: Modely závažných lidských onemocnění: Traumatické poškození míchy, Huntingtonova choroba, melanom a neplodnost</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Translational Research in Serious Human Diseases

ISBN

978-80-200-3158-7

Počet stran výsledku

6

Strana od-do

37-42

Počet stran knihy

271

Název nakladatele

Academia

Místo vydání

Praha

Kód UT WoS kapitoly

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