Genetic causes and animal models of basal ganglia related disorders - I. Parkinson´s disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F20%3A00536503" target="_blank" >RIV/67985904:_____/20:00536503 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Genetic causes and animal models of basal ganglia related disorders - I. Parkinson´s disease

Popis výsledku v původním jazyce

Striatum is the area of basal ganglia known as an important regulator of motor output. Inhibitory GABAergic medium spiny neurons (MSNs) are predominant neuronal population of the striatum.nFunctional imbalances and disruptions in their function are associated with abnormal function of the striatum and play a role in several movement disorders. Huntington disease is probably the bestknown movement disorder affecting striatum. However, secondary striatal dysfunction plays an important role also in Parkinson's disease (PD). In our review, we provide short overview of this neurodegenerative disease, its clinical features and current therapeutical approaches, but mainly focus on summarising current knowledge of underlying genetic causes of PD and available animal models of this serious disease.

Název v anglickém jazyce

Genetic causes and animal models of basal ganglia related disorders - I. Parkinson´s disease

Popis výsledku anglicky

Striatum is the area of basal ganglia known as an important regulator of motor output. Inhibitory GABAergic medium spiny neurons (MSNs) are predominant neuronal population of the striatum.nFunctional imbalances and disruptions in their function are associated with abnormal function of the striatum and play a role in several movement disorders. Huntington disease is probably the bestknown movement disorder affecting striatum. However, secondary striatal dysfunction plays an important role also in Parkinson's disease (PD). In our review, we provide short overview of this neurodegenerative disease, its clinical features and current therapeutical approaches, but mainly focus on summarising current knowledge of underlying genetic causes of PD and available animal models of this serious disease.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/LO1609" target="_blank" >LO1609: Modely závažných lidských onemocnění: Traumatické poškození míchy, Huntingtonova choroba, melanom a neplodnost</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Translational Research in Serious Human Diseases

ISBN

978-80-200-3158-7

Počet stran výsledku

12

Strana od-do

64-75

Počet stran knihy

271

Název nakladatele

Academia

Místo vydání

Praha

Kód UT WoS kapitoly

—