Targeted proteomics in translational research of neurodegenerative diseases

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F20%3A00536527" target="_blank" >RIV/67985904:_____/20:00536527 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Targeted proteomics in translational research of neurodegenerative diseases

Popis výsledku v původním jazyce

With recent technical improvements in the field of mass spectrometry-based analysis of proteins, the technology is now ready to enter clinical laboratories for routine measurements of protein biomarkers. Targeted MS methods like selected reaction monitoring or recently presented parallel reaction monitoring showed a great potential for sensitive, selective, and robust assays. Ease of development and multiplexing capacity of these methods is especially suitable for verification and validation of proteomics discovery data. The translation of preclinical findings in research of neurodegenerative disorders into practical use now relies on necessary implementation of independent tightly controlled clinical studies on a large cohort of well-defined subjects. In our review we briefly describe the targeted proteomics techniques and their employment in clinical proteomics validation of neurodegeneration biomarkers, with hope to identify disease diagnostic, prognostic or predictive biomarkers.

Název v anglickém jazyce

Targeted proteomics in translational research of neurodegenerative diseases

Popis výsledku anglicky

With recent technical improvements in the field of mass spectrometry-based analysis of proteins, the technology is now ready to enter clinical laboratories for routine measurements of protein biomarkers. Targeted MS methods like selected reaction monitoring or recently presented parallel reaction monitoring showed a great potential for sensitive, selective, and robust assays. Ease of development and multiplexing capacity of these methods is especially suitable for verification and validation of proteomics discovery data. The translation of preclinical findings in research of neurodegenerative disorders into practical use now relies on necessary implementation of independent tightly controlled clinical studies on a large cohort of well-defined subjects. In our review we briefly describe the targeted proteomics techniques and their employment in clinical proteomics validation of neurodegeneration biomarkers, with hope to identify disease diagnostic, prognostic or predictive biomarkers.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/LO1609" target="_blank" >LO1609: Modely závažných lidských onemocnění: Traumatické poškození míchy, Huntingtonova choroba, melanom a neplodnost</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Translational Research in Serious Human Diseases

ISBN

978-80-200-3158-7

Počet stran výsledku

11

Strana od-do

112-122

Počet stran knihy

271

Název nakladatele

Academia

Místo vydání

Praha

Kód UT WoS kapitoly

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