The role of metalloproteinases in eye wounding and healing
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F20%3A00536566" target="_blank" >RIV/67985904:_____/20:00536566 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The role of metalloproteinases in eye wounding and healing
Popis výsledku v původním jazyce
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that play a significant role in extracellular matrix (ECM) remodelling, signal transduction, proliferation, migration, and contraction. MMPs are involved in tissue inflammation and leukocyte infiltration, and engaged in embryogenesis, morphogenesis, angiogenesis, and wound repair. Additionally, MMPs take part in the various processes during pathological conditions, including osteoarthritis, cancer, and neovascularization. All structures of the eye consist of a large amount of EXM that provides normal functioning of the ocular system. Therefore, even a little misbalance of MMPs and the tissue inhibitors of metalloproteases (TIMPs) in the eye tissue can lead to the disorders. Consequently, investigation of MMPs with TIMPs and elucidating molecular mechanisms is significant to further development of new therapies for eye disease treatment.
Název v anglickém jazyce
The role of metalloproteinases in eye wounding and healing
Popis výsledku anglicky
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that play a significant role in extracellular matrix (ECM) remodelling, signal transduction, proliferation, migration, and contraction. MMPs are involved in tissue inflammation and leukocyte infiltration, and engaged in embryogenesis, morphogenesis, angiogenesis, and wound repair. Additionally, MMPs take part in the various processes during pathological conditions, including osteoarthritis, cancer, and neovascularization. All structures of the eye consist of a large amount of EXM that provides normal functioning of the ocular system. Therefore, even a little misbalance of MMPs and the tissue inhibitors of metalloproteases (TIMPs) in the eye tissue can lead to the disorders. Consequently, investigation of MMPs with TIMPs and elucidating molecular mechanisms is significant to further development of new therapies for eye disease treatment.
Klasifikace
Druh
C - Kapitola v odborné knize
CEP obor
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OECD FORD obor
10603 - Genetics and heredity (medical genetics to be 3)
Návaznosti výsledku
Projekt
<a href="/cs/project/LO1609" target="_blank" >LO1609: Modely závažných lidských onemocnění: Traumatické poškození míchy, Huntingtonova choroba, melanom a neplodnost</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2020
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název knihy nebo sborníku
Translational Research in Serious Human Diseases
ISBN
978-80-200-3158-7
Počet stran výsledku
7
Strana od-do
160-166
Počet stran knihy
271
Název nakladatele
Academia
Místo vydání
Praha
Kód UT WoS kapitoly
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