Melanoma progression and spontaneous regression in the Melanoma-bearing Libechov Minipig (MeLiM) model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F20%3A00536610" target="_blank" >RIV/67985904:_____/20:00536610 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Melanoma progression and spontaneous regression in the Melanoma-bearing Libechov Minipig (MeLiM) model

Popis výsledku v původním jazyce

Cutaneous melanoma is a malignant tumour arising by neoplastic transformation of melanocytes, normal skin melanin-containing cells. It is the most dangerous skin cancer with worldwide incidence in Caucasian population increasing during the last decades. Despite present successes in the melanoma treatment using immune checkpoint inhibitors, its therapy in metastatic stage is still unsatisfactory and new approaches need to be sought. The Melanoma-bearing Libechov Minipig (MeLiM) is a unique model of hereditary metastatic melanoma which shows histopathological, immunohistochemical, biochemical, haematological, and genetic similarities with the human melanoma. Long-term monitoring and detailed analyses of affected animals allow identifying genes and understanding the biological processes associated with the melanoma development and progression as well as its spontaneous regression. In addition, new techniques for melanoma treatment can be tested using MeLiM piglets with progressing melanoma. Tumour devitalization (surgical ischaemization) was successfully utilized in animals with metastatic melanoma and multiple cutaneousntumours. Increased expression of heat shock proteins HSP70 and gp96 in the devitalized melanoma followed by increased population of tumour infiltrating lymphocytes in all untreated melanomas and generalized destruction of melanoma cells in all cancer deposits including organ metastases were observed in the treated pigs. They were in long-term remission without relapse. MeLiM represents a valuable large animal model to study melanoma regression and new methods for melanoma treatment.

Název v anglickém jazyce

Melanoma progression and spontaneous regression in the Melanoma-bearing Libechov Minipig (MeLiM) model

Popis výsledku anglicky

Cutaneous melanoma is a malignant tumour arising by neoplastic transformation of melanocytes, normal skin melanin-containing cells. It is the most dangerous skin cancer with worldwide incidence in Caucasian population increasing during the last decades. Despite present successes in the melanoma treatment using immune checkpoint inhibitors, its therapy in metastatic stage is still unsatisfactory and new approaches need to be sought. The Melanoma-bearing Libechov Minipig (MeLiM) is a unique model of hereditary metastatic melanoma which shows histopathological, immunohistochemical, biochemical, haematological, and genetic similarities with the human melanoma. Long-term monitoring and detailed analyses of affected animals allow identifying genes and understanding the biological processes associated with the melanoma development and progression as well as its spontaneous regression. In addition, new techniques for melanoma treatment can be tested using MeLiM piglets with progressing melanoma. Tumour devitalization (surgical ischaemization) was successfully utilized in animals with metastatic melanoma and multiple cutaneousntumours. Increased expression of heat shock proteins HSP70 and gp96 in the devitalized melanoma followed by increased population of tumour infiltrating lymphocytes in all untreated melanomas and generalized destruction of melanoma cells in all cancer deposits including organ metastases were observed in the treated pigs. They were in long-term remission without relapse. MeLiM represents a valuable large animal model to study melanoma regression and new methods for melanoma treatment.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

<a href="/cs/project/LO1609" target="_blank" >LO1609: Modely závažných lidských onemocnění: Traumatické poškození míchy, Huntingtonova choroba, melanom a neplodnost</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Translational Research in Serious Human Diseases

ISBN

978-80-200-3158-7

Počet stran výsledku

14

Strana od-do

187-200

Počet stran knihy

271

Název nakladatele

Academia

Místo vydání

Praha

Kód UT WoS kapitoly

—