A gene copy number arms race in action: X,Y-chromosome transmission distortion across a species barrier

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F23%3A00571306" target="_blank" >RIV/67985904:_____/23:00571306 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68081766:_____/23:00571306 RIV/00216224:14310/23:00132105

Výsledek na webu

<a href="https://academic.oup.com/evolut/advance-article/doi/10.1093/evolut/qpad051/7085198" target="_blank" >https://academic.oup.com/evolut/advance-article/doi/10.1093/evolut/qpad051/7085198</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/evolut/qpad051" target="_blank" >10.1093/evolut/qpad051</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A gene copy number arms race in action: X,Y-chromosome transmission distortion across a species barrier

Popis výsledku v původním jazyce

A remarkable gene copy number (CN) arms race system has recently been described in laboratory mice, where Slx, Slxl1 and Sly genes compete over transmission by altering the fertilization success of X and Y chromosome-bearing sperm, respectively. Here, we focus on this system in nature, where natural selection can counter CN/gene product escalation. Our model is house mouse subspecies hybridizing in Europe. In some regions, Y chromosomes of the Eastern subspecies have introgressed onto Western genomic backgrounds, accompanied by sex ratio distortion in favor of males, consistent with the inbred lines suggested mechanism: Overabundance of SLY protein expressed by invading Y chromosomes. We take Slx as representative of the X side of this arms race and measure Slx|Sly CN and expression across an 'Invasion' transect where Ys introgress and a 'Control' transect with negligible introgression. Since we found similar Slx|Sly ratios in both transects, SLY overabundance is unlikely to explain the introgression. However, Slx CN is relatively low in the introgression area, suggesting that Slx is less able to combat Sly effects here. Furthermore, deterministic changes in Slx|Sly expression proportions versus CN proportions suggest standing variation for trans regulation of Slx|Sly is being co-opted in nature where their arms race reduces population fitness.

Název v anglickém jazyce

A gene copy number arms race in action: X,Y-chromosome transmission distortion across a species barrier

Popis výsledku anglicky

A remarkable gene copy number (CN) arms race system has recently been described in laboratory mice, where Slx, Slxl1 and Sly genes compete over transmission by altering the fertilization success of X and Y chromosome-bearing sperm, respectively. Here, we focus on this system in nature, where natural selection can counter CN/gene product escalation. Our model is house mouse subspecies hybridizing in Europe. In some regions, Y chromosomes of the Eastern subspecies have introgressed onto Western genomic backgrounds, accompanied by sex ratio distortion in favor of males, consistent with the inbred lines suggested mechanism: Overabundance of SLY protein expressed by invading Y chromosomes. We take Slx as representative of the X side of this arms race and measure Slx|Sly CN and expression across an 'Invasion' transect where Ys introgress and a 'Control' transect with negligible introgression. Since we found similar Slx|Sly ratios in both transects, SLY overabundance is unlikely to explain the introgression. However, Slx CN is relatively low in the introgression area, suggesting that Slx is less able to combat Sly effects here. Furthermore, deterministic changes in Slx|Sly expression proportions versus CN proportions suggest standing variation for trans regulation of Slx|Sly is being co-opted in nature where their arms race reduces population fitness.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Evolution

ISSN

0014-3820

e-ISSN

1558-5646

Svazek periodika

77

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

1330-1340

Kód UT WoS článku

000963833400001

EID výsledku v databázi Scopus

2-s2.0-85178302563