Spatiotemporal monitoring of hard tissue development reveals unknown features of tooth and bone development

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F23%3A00575031" target="_blank" >RIV/67985904:_____/23:00575031 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/23:00131746 RIV/00216305:26620/23:PU148889 RIV/46747885:24220/23:00011497 RIV/00216208:11110/23:10466882

Výsledek na webu

<a href="https://www.science.org/doi/10.1126/sciadv.adi0482" target="_blank" >https://www.science.org/doi/10.1126/sciadv.adi0482</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1126/sciadv.adi0482" target="_blank" >10.1126/sciadv.adi0482</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Spatiotemporal monitoring of hard tissue development reveals unknown features of tooth and bone development

Popis výsledku v původním jazyce

Mineralized tissues, such as bones or teeth, are essential structures of all vertebrates. They enable rapid movement, protection, and food processing, in addition to providing physiological functions. Although the development, regeneration, and pathogenesis of teeth and bones have been intensely studied, there is currently no tool to accurately follow the dynamics of growth and healing of these vital tissues in space and time. Here, we present the BEE-ST (Bones and tEEth Spatio-Temporal growth monitoring) approach, which allows precise quantification of development, regeneration, remodeling, and healing in any type of calcified tissue across different species. Using mouse teeth as model the turnover rate of continuously growing incisors was quantified, and role of hard/soft diet on molar root growth was shown. Furthermore, the dynamics of bones and teeth growth in lizards, frogs, birds, and zebrafish was uncovered. This approach represents an effective, highly reproducible, and versatile tool that opens up diverse possibilities in developmental biology, bone and tooth healing, tissue engineering, and disease modeling.

Název v anglickém jazyce

Spatiotemporal monitoring of hard tissue development reveals unknown features of tooth and bone development

Popis výsledku anglicky

Mineralized tissues, such as bones or teeth, are essential structures of all vertebrates. They enable rapid movement, protection, and food processing, in addition to providing physiological functions. Although the development, regeneration, and pathogenesis of teeth and bones have been intensely studied, there is currently no tool to accurately follow the dynamics of growth and healing of these vital tissues in space and time. Here, we present the BEE-ST (Bones and tEEth Spatio-Temporal growth monitoring) approach, which allows precise quantification of development, regeneration, remodeling, and healing in any type of calcified tissue across different species. Using mouse teeth as model the turnover rate of continuously growing incisors was quantified, and role of hard/soft diet on molar root growth was shown. Furthermore, the dynamics of bones and teeth growth in lizards, frogs, birds, and zebrafish was uncovered. This approach represents an effective, highly reproducible, and versatile tool that opens up diverse possibilities in developmental biology, bone and tooth healing, tissue engineering, and disease modeling.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10601 - Cell biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Science Advances

ISSN

2375-2548

e-ISSN

2375-2548

Svazek periodika

9

Číslo periodika v rámci svazku

31

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

17

Strana od-do

eadi0482

Kód UT WoS článku

001041633500015

EID výsledku v databázi Scopus

2-s2.0-85166402106