Extracellular Vesicles as Possible Sources of Huntington’s Disease Biomarkers

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F23%3A00577186" target="_blank" >RIV/67985904:_____/23:00577186 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/23:10477013

Výsledek na webu

<a href="http://dx.doi.org/10.1007/978-3-031-32815-2_3" target="_blank" >http://dx.doi.org/10.1007/978-3-031-32815-2_3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-3-031-32815-2_3" target="_blank" >10.1007/978-3-031-32815-2_3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Extracellular Vesicles as Possible Sources of Huntington’s Disease Biomarkers

Popis výsledku v původním jazyce

Extracellular vesicles (EVs) are membrane enveloped particles released from cells to the extracellular environment and body fluids. During their biosynthesis, lipids, proteins, nucleic acids, metabolites and other molecules of the EV producing cell are incorporated into EVs. EVs are able to transfer such molecular cargo to recipient cells and thus participate in intercellular communication. In this chapter, we review the current knowledge about EVs in a rare hereditary neurodegenerative disorder, Huntington’s disease (HD), which is caused by expanded polyglutamine sequence in protein huntingtin. The roles of EVs in HD are presented from several aspects, including the roles of EVs in disease pathogenesis and transfer of mutant huntingtin, EV importance in the search of HD biomarkers with a special focus on proteins and miRNAs, and experimental therapeutic applications of astrocyte- and stem cell-derived EVs as well as engineered EVs in HD.

Název v anglickém jazyce

Extracellular Vesicles as Possible Sources of Huntington’s Disease Biomarkers

Popis výsledku anglicky

Extracellular vesicles (EVs) are membrane enveloped particles released from cells to the extracellular environment and body fluids. During their biosynthesis, lipids, proteins, nucleic acids, metabolites and other molecules of the EV producing cell are incorporated into EVs. EVs are able to transfer such molecular cargo to recipient cells and thus participate in intercellular communication. In this chapter, we review the current knowledge about EVs in a rare hereditary neurodegenerative disorder, Huntington’s disease (HD), which is caused by expanded polyglutamine sequence in protein huntingtin. The roles of EVs in HD are presented from several aspects, including the roles of EVs in disease pathogenesis and transfer of mutant huntingtin, EV importance in the search of HD biomarkers with a special focus on proteins and miRNAs, and experimental therapeutic applications of astrocyte- and stem cell-derived EVs as well as engineered EVs in HD.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/GA19-01747S" target="_blank" >GA19-01747S: Proteomická analýza extracelulárních váčků u Huntingtonovy nemoci</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Biomarkers for Huntington's Disease

ISBN

978-3-031-32814-5

Počet stran výsledku

31

Strana od-do

45-75

Počet stran knihy

475

Název nakladatele

Springer

Místo vydání

Cham

Kód UT WoS kapitoly

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