Unifying framework explaining how parental regulatory divergence can drive gene expression in hybrids and allopolyploids

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F24%3A00600014" target="_blank" >RIV/67985904:_____/24:00600014 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388963:_____/24:00600014 RIV/60076658:12310/24:43908288 RIV/60076658:12520/24:43908288 RIV/61988987:17310/24:A2503ANE

Výsledek na webu

<a href="https://www.nature.com/articles/s41467-024-52546-5" target="_blank" >https://www.nature.com/articles/s41467-024-52546-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41467-024-52546-5" target="_blank" >10.1038/s41467-024-52546-5</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Unifying framework explaining how parental regulatory divergence can drive gene expression in hybrids and allopolyploids

Popis výsledku v původním jazyce

Hybridization and polyploidy are powerful evolutionary forces, inducing a range of phenotypic outcomes, including non-additive expression, subgenome dominance, deviations in genomic dosage, and transcriptome downsizing. The reasons for these patterns and whether they are universal adaptive responses to genome merging and doubling remain debated. To address this, we develop a thermodynamic model of gene expression based on transcription factor (TF)-promoter binding. Applied to hybridization between species with divergent gene expression levels, cell volumes, or euchromatic ratios, this model distinguishes the effects of hybridization from those of polyploidy. Our results align with empirical observations, suggesting that gene regulation patterns in hybrids and polyploids often stem from the constrained interplay between inherited diverged regulatory networks rather than from subsequent adaptive evolution. In addition, occurrence of certain phenotypic traits depend on specific assumptions about promoter-TF coevolution and their distribution within the hybrid's nucleoplasm, offering new research avenues to understand the underlying mechanisms. In summary, our model explains how the legacy of divergent species directly influences the phenotypic traits of hybrids and allopolyploids.nHybridization and polyploidization influence gene expression with several prominent trends. This study uses a thermodynamic model to show that many observed gene expression patterns in hybrids and allopolyploids can be explained by regulatory divergence between parents, revealing the complex interplay of admixed regulatory networks.

Název v anglickém jazyce

Unifying framework explaining how parental regulatory divergence can drive gene expression in hybrids and allopolyploids

Popis výsledku anglicky

Hybridization and polyploidy are powerful evolutionary forces, inducing a range of phenotypic outcomes, including non-additive expression, subgenome dominance, deviations in genomic dosage, and transcriptome downsizing. The reasons for these patterns and whether they are universal adaptive responses to genome merging and doubling remain debated. To address this, we develop a thermodynamic model of gene expression based on transcription factor (TF)-promoter binding. Applied to hybridization between species with divergent gene expression levels, cell volumes, or euchromatic ratios, this model distinguishes the effects of hybridization from those of polyploidy. Our results align with empirical observations, suggesting that gene regulation patterns in hybrids and polyploids often stem from the constrained interplay between inherited diverged regulatory networks rather than from subsequent adaptive evolution. In addition, occurrence of certain phenotypic traits depend on specific assumptions about promoter-TF coevolution and their distribution within the hybrid's nucleoplasm, offering new research avenues to understand the underlying mechanisms. In summary, our model explains how the legacy of divergent species directly influences the phenotypic traits of hybrids and allopolyploids.nHybridization and polyploidization influence gene expression with several prominent trends. This study uses a thermodynamic model to show that many observed gene expression patterns in hybrids and allopolyploids can be explained by regulatory divergence between parents, revealing the complex interplay of admixed regulatory networks.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nature Communications

ISSN

2041-1723

e-ISSN

2041-1723

Svazek periodika

15

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

16

Strana od-do

8714

Kód UT WoS článku

001331421200024

EID výsledku v databázi Scopus

2-s2.0-85205985805