Secondary target organs exhibit differential ability to clear cadmium after cadmium oxide nanoparticle inhalation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F25%3A00638999" target="_blank" >RIV/67985904:_____/25:00638999 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68081715:_____/25:00638999 RIV/00216224:14110/25:00144396 RIV/00216305:26620/26:0198660 RIV/44994575:_____/25:10002460

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0304389425020977?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0304389425020977?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jhazmat.2025.139181" target="_blank" >10.1016/j.jhazmat.2025.139181</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Secondary target organs exhibit differential ability to clear cadmium after cadmium oxide nanoparticle inhalation

Popis výsledku v původním jazyce

Inhaled cadmium oxide nanoparticles (CdONPs) represent an underrecognized environmental and occupational hazard because of their potential for systemic bioaccumulation and organ-specific toxicity. In this study, mice were exposed to subchronic inhalation of CdONPs, and cadmium distribution, clearance, and tissue responses were assessed over a 21-day recovery period using atomic absorption spectrometry, laser ablation inductively coupled plasma mass spectrometry, histopathology, and gene expression analysis. Cadmium accumulated predominantly in the lungs, where clearance was slow and accompanied by persistent inflammation and foam cell formation. The intestines exhibited efficient cadmium reduction, likely due to high epithelial turnover, while the liver showed minimal accumulation and no overt damage. By contrast, the kidneys retained cadmium pri-marily in the cortex, with partial clearance and ultrastructural changes, including mitochondrial disorganization and lipid accumulation. Bone tissues demonstrated differential retention: jaw bones effectively cleared cadmium, whereas femurs showed sustained or increased levels, suggesting redistribution from other organs. Gene expression analysis revealed moderate but consistent upregulation of Abca1, Apoe, and Ptch1 in the kidneys of clearance groups, indicating adaptations in lipid metabolism and membrane transport. These findings highlight organ-specific clearance kinetics and molecular responses to inhaled CdONPs, underscoring the need for tissue-targeted risk assessment frameworks in nanoparticle toxicology.

Název v anglickém jazyce

Secondary target organs exhibit differential ability to clear cadmium after cadmium oxide nanoparticle inhalation

Popis výsledku anglicky

Inhaled cadmium oxide nanoparticles (CdONPs) represent an underrecognized environmental and occupational hazard because of their potential for systemic bioaccumulation and organ-specific toxicity. In this study, mice were exposed to subchronic inhalation of CdONPs, and cadmium distribution, clearance, and tissue responses were assessed over a 21-day recovery period using atomic absorption spectrometry, laser ablation inductively coupled plasma mass spectrometry, histopathology, and gene expression analysis. Cadmium accumulated predominantly in the lungs, where clearance was slow and accompanied by persistent inflammation and foam cell formation. The intestines exhibited efficient cadmium reduction, likely due to high epithelial turnover, while the liver showed minimal accumulation and no overt damage. By contrast, the kidneys retained cadmium pri-marily in the cortex, with partial clearance and ultrastructural changes, including mitochondrial disorganization and lipid accumulation. Bone tissues demonstrated differential retention: jaw bones effectively cleared cadmium, whereas femurs showed sustained or increased levels, suggesting redistribution from other organs. Gene expression analysis revealed moderate but consistent upregulation of Abca1, Apoe, and Ptch1 in the kidneys of clearance groups, indicating adaptations in lipid metabolism and membrane transport. These findings highlight organ-specific clearance kinetics and molecular responses to inhaled CdONPs, underscoring the need for tissue-targeted risk assessment frameworks in nanoparticle toxicology.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

21002 - Nano-processes (applications on nano-scale); (biomaterials to be 2.9)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Hazardous Materials

ISSN

0304-3894

e-ISSN

1873-3336

Svazek periodika

496

Číslo periodika v rámci svazku

SEP15

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

24

Strana od-do

139181

Kód UT WoS článku

001538473000001

EID výsledku v databázi Scopus

2-s2.0-105010954776