A migration-driven model for the historical spread of leprosy in medieval Eastern and Central Europe

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985912%3A_____%2F15%3A00448989" target="_blank" >RIV/67985912:_____/15:00448989 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023272:_____/15:#0002752

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.meegid.2015.02.001" target="_blank" >http://dx.doi.org/10.1016/j.meegid.2015.02.001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.meegid.2015.02.001" target="_blank" >10.1016/j.meegid.2015.02.001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A migration-driven model for the historical spread of leprosy in medieval Eastern and Central Europe

Popis výsledku v původním jazyce

Leprosy was rare in Europe during the Roman period, yet its prevalence increased dramatically in medieval times. We examined human remains, with paleopathological lesions indicative of leprosy, dated to the 6th-11th century AD, from Central and Eastern Europe and Byzantine Anatolia. Analysis of ancient DNA and bacterial cell wall lipid biomarkers revealed Mycobacterium leprae in skeletal remains from 6th-8th century Northern Italy, 7th-11th century Hungary, 8th-9th century Austria, the Slavic Greater Moravian Empire of the 9th-10th century and 8th-10th century Byzantine samples from Northern Anatolia. These data were analyzed alongside findings published by others. M. leprae is an obligate human pathogen that has undergone an evolutionary bottleneck followed by clonal expansion. Therefore M. leprae genotypes and sub-genotypes give information about the human populations they have infected and their migration. Although data are limited, genotyping demonstrates that historical M. leprae

Název v anglickém jazyce

A migration-driven model for the historical spread of leprosy in medieval Eastern and Central Europe

Popis výsledku anglicky

Leprosy was rare in Europe during the Roman period, yet its prevalence increased dramatically in medieval times. We examined human remains, with paleopathological lesions indicative of leprosy, dated to the 6th-11th century AD, from Central and Eastern Europe and Byzantine Anatolia. Analysis of ancient DNA and bacterial cell wall lipid biomarkers revealed Mycobacterium leprae in skeletal remains from 6th-8th century Northern Italy, 7th-11th century Hungary, 8th-9th century Austria, the Slavic Greater Moravian Empire of the 9th-10th century and 8th-10th century Byzantine samples from Northern Anatolia. These data were analyzed alongside findings published by others. M. leprae is an obligate human pathogen that has undergone an evolutionary bottleneck followed by clonal expansion. Therefore M. leprae genotypes and sub-genotypes give information about the human populations they have infected and their migration. Although data are limited, genotyping demonstrates that historical M. leprae

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

AC - Archeologie, antropologie, etnologie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Infection, Genetics and Evolution

ISSN

1567-1348

e-ISSN

—

Svazek periodika

31

Číslo periodika v rámci svazku

April

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

250-256

Kód UT WoS článku

000352182900034

EID výsledku v databázi Scopus

2-s2.0-84923030250