Population history and genetic adaptation of the Fulani nomads: inferences from genome-wide data and the lactase persistence trait

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985912%3A_____%2F19%3A00517502" target="_blank" >RIV/67985912:_____/19:00517502 - isvavai.cz</a>

Výsledek na webu

<a href="https://bmcgenomics.biomedcentral.com/track/pdf/10.1186/s12864-019-6296-7" target="_blank" >https://bmcgenomics.biomedcentral.com/track/pdf/10.1186/s12864-019-6296-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12864-019-6296-7" target="_blank" >10.1186/s12864-019-6296-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Population history and genetic adaptation of the Fulani nomads: inferences from genome-wide data and the lactase persistence trait

Popis výsledku v původním jazyce

Through several genomic analyses we show that the present-day Fulani diversity is the result of an admixture between a West African group and a group/s that carried European and North African ancestry. The European variant associated with lactase persistence (capacity to digest lactose in adulthood) was likely introduced through this admixture event, and was strongly selected in successive generations. We show also that the region with the lactase gene was not the only one that was under strong selective pressure in the ancestral population leading to the contemporary Fulani pastoralists as several other selection signals were detected in our dataset. It can be suggested that these genetic advantages contributed to population expansion of the pastoralists and long range spread across the Sahel/Savannah belt of Africa.

Název v anglickém jazyce

Population history and genetic adaptation of the Fulani nomads: inferences from genome-wide data and the lactase persistence trait

Popis výsledku anglicky

Through several genomic analyses we show that the present-day Fulani diversity is the result of an admixture between a West African group and a group/s that carried European and North African ancestry. The European variant associated with lactase persistence (capacity to digest lactose in adulthood) was likely introduced through this admixture event, and was strongly selected in successive generations. We show also that the region with the lactase gene was not the only one that was under strong selective pressure in the ancestral population leading to the contemporary Fulani pastoralists as several other selection signals were detected in our dataset. It can be suggested that these genetic advantages contributed to population expansion of the pastoralists and long range spread across the Sahel/Savannah belt of Africa.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

60102 - Archaeology

Projekt

<a href="/cs/project/GA19-09352S" target="_blank" >GA19-09352S: Genomické adaptace a molekulární ekologie potravně produkčních systémů</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BMC Genomics

ISSN

1471-2164

e-ISSN

—

Svazek periodika

20

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

915

Kód UT WoS článku

000501323300001

EID výsledku v databázi Scopus

2-s2.0-85076088989